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Product Name:Curculigoside C
CAS:851713-74-1
Purity:>=98% Package:5mg ,10mg ,20mg ,50mg ,100mg; 200mg; 500mg,可根据客户需求定制 Remarks:1308/5mg
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Product Name:Curculigoside C
CAS:851713-74-1
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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Product Name:Curculigoside C
CAS:851713-74-1
Purity:HPLC>=98% Package:20mg Remarks:B23194
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Product Name:Curculigoside C
CAS:851713-74-1
Purity:95% HPLC Package:5KG;1KG;500G;100G;50G
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| | Curculigoside C Basic information |
| Product Name: | Curculigoside C | | Synonyms: | Curculigoside C;β-D-Glucopyranoside, 4-hydroxy-2-[[(3-hydroxy-2,6-dimethoxybenzoyl)oxy]methyl]phenyl | | CAS: | 851713-74-1 | | MF: | C22H26O12 | | MW: | 482.43 | | EINECS: | | | Product Categories: | | | Mol File: | 851713-74-1.mol |  |
| | Curculigoside C Chemical Properties |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | form | Powder |
| | Curculigoside C Usage And Synthesis |
| Uses | Curculigoside C is a phenolic glucoside with potent antioxidative and neuroprotective activities. Curculigoside C shows IC50 values of 0.25 mM and 0.88 mM for hydroxyl radicals and superoxide anion radicals, respectively[1]. | | in vivo | Curculigoside C (15, 30 and 60 mg/kg) exhibits rapid oral absorption (Tmax = 0.106 h, 0.111 h, and 0.111 h, respectively), high elimination (t1/2 = 2.022 h, 2.061 h, and 2.048 h, respectively) and low absolute bioavailability (2.01%, 2.13%, and 2.39%, respectively)[2].
Pharmacokinetic parameters of CC in rat plasma after intragastric administration[1].
| Dose (mg/kg) | t1/2 (h) | AUC0-60 (μg/L/h) | AUC0-∞ (μg/L/h) | F (%) | Vd (L/kg) | CLz (L/h/kg) | | 15 | 2.022 ± 0.184 | 0.106 ± 0.149 | 62.731 ± 10.149 | 66.310 ± 10.563 | 2.01 | 673.157 ± 116.509 | 231.036 ± 36.69 | | 30 | 2.061 ± 0.325 | 0.111 ± 0.043 | 133.17 ± 48.434 | 140.656 ± 48.335 | 2.13 | 722.605 ± 316.306 | 234.188 ± 74.864 | | 60 | 2.048 ± 0.227 | 0.111 ± 0.043 | 299.155 ± 80.954 | 316.980 ± 91.704 | 2.39 | 585.344 ± 124.289 | 201.905 ± 55.193 | | 2.0 (i.v) | 1.153 ± 0.203 | - | 416.700 ± 70.401 | 420.700 ± 70.690 | - | 8.122 ± 1.973 | 4.869 ± 0.834 |
| | References | [1] Wu Q, et al. Antioxidative phenols and phenolic glycosides from Curculigo orchioides. Chem Pharm Bull (Tokyo). 2005 Aug;53(8):1065-7. DOI:10.1248/cpb.53.1065
[2] Di Wu, et al. Pharmacokinetic and Metabolism Studies of Curculigoside C by UPLC-MS/MS and UPLC-QTOF-MS. Molecules. 2018 Dec 21;24(1):21. DOI:10.3390/molecules24010021 |
| | Curculigoside C Preparation Products And Raw materials |
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