- Prednisolone Acetate
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- $20.00/ kg
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2024-04-26
- CAS:52-21-1
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 20
- Prednisolone Acetate
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- $9.00 / 1g
-
2024-04-26
- CAS:52-21-1
- Min. Order: 10g
- Purity: min99%
- Supply Ability: 10 tons
- Prednisolone Acetate
-
- $0.00 / 1kg
-
2024-04-23
- CAS:52-21-1
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 20tons
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| | Prednisolone-21-acetate Basic information |
| Product Name: | Prednisolone-21-acetate | | Synonyms: | PRICORTIN;1,4-PREGNADIENE-11BETA,17ALPHA,21-TRIOL 3,20-DIONE 21-ACETATE;1,4-PREGNADIENE-3,20-DIONE-11BETA,17ALPHA,21-TRIOL 21-ACETATE;1,4-PREGNADIEN-11BETA,17ALPHA,21-TRIOL-3,20-DIONE 21-ACETATE;1,4-PREGNADIEN-11-BETA, 17,21-TRIOL-3,20-DIONE 21-ACETATE;1-DEHYDROCORTISOL 21-ACETATE;21-ACETOXY-1,4-PREGNADIENE-11BETA,17ALPHA-DIOL-3,20-DIONE;METACORTANDROLONE ACETATE | | CAS: | 52-21-1 | | MF: | C23H30O6 | | MW: | 402.49 | | EINECS: | 200-134-1 | | Product Categories: | Applicable to rheumatoid arthritis, rheumatic fever, lupus erythematosus (sle), scleroderma, dermatomyositis, acute lymphocytic leukemia, etc;METICOTOLONE;API;Biochemistry;Hydroxyketosteroids;Steroids;Intermediates & Fine Chemicals;Pharmaceuticals;52-21-1 | | Mol File: | 52-21-1.mol |  |
| | Prednisolone-21-acetate Chemical Properties |
| Melting point | 240-244 °C | | alpha | D25 +116° (dioxane) | | Boiling point | 579.8±50.0 °C(Predicted) | | density | 1.28±0.1 g/cm3(Predicted) | | refractive index | 112 ° (C=1, Dioxane) | | storage temp. | 2-8°C | | solubility | Practically insoluble in water, slightly soluble in ethanol (96 per cent) and in methylene chloride. | | pka | 12.41±0.70(Predicted) | | color | White to Off-White | | Water Solubility | 11.6mg/L(25 ºC) | | Merck | 7721 | | BRN | 3111798 | | Stability: | Stable. Incompatible with strong oxidizing agents. | | CAS DataBase Reference | 52-21-1(CAS DataBase Reference) | | NIST Chemistry Reference | 1,4-Pregnadiene-3,20-dione, 11beta,17alpha,21-trihydroxy-, acetate(52-21-1) |
| | Prednisolone-21-acetate Usage And Synthesis |
| Chemical Properties | White or almost white, crystalline powder. | | Originator | Sterane, Phipharmex ,US ,1955 | | Uses | glucocorticoid | | Uses | Synthetic corticosteroid; metabolically interconvertible with prednisone. | | Definition | ChEBI: Prednisolone acetate is a corticosteroid hormone. | | Manufacturing Process | To a solution of 0.85 gram of 1,4-pregnadiene-11β,17α,21-triol-3,20-dione (prednisolone) in 5 ml of pyridine are added 3 ml of acetic anhydride. The reaction mixture is allowed to stand at room temperature overnight and is then diluted with ice water. The resulting precipitate is filtered from the mixture and recrystallized from acetone-hexane. There is recovered 0.45 gram of 1,4-pregnadiene-11β,17α,21-triol-3,20-dione 21-acetate, MP 235°239°C. On recrystallization, the MP rose to 237°-239°C. | | Brand name | Econopred (Alcon); Meticortelone (Schering); Omnipred (Alcon); Sterane (Pfizer). | | Therapeutic Function | Glucocorticoid | | Biological Activity | Prednisolone Acetate (Omnipred) is a synthetic corticosteroid that is a particularly potent immunosuppressant. | | Clinical Use | For rheumatoid arthritis, rheumatic fever, lupus erythematosus, scleroderma, dermatomyositis, acute lymphoblastic leukemia, etc. | | Purification Methods | Recrystallise prednisolone acetate from EtOH, Me2CO, Me2CO/hexane, and it has UV with max at 243nm in EtOH. [Joly et al. Bull Soc Chim Fr 366 1958; Herzog et al. J Am Chem Soc 77 4781 1955, Beilstein 8 IV 3468.] |
| | Prednisolone-21-acetate Preparation Products And Raw materials |
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