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Cortisone acetate

Cortisone acetate Suppliers list
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Products Intro: Product Name:Cortisone acetate
CAS:50-04-4
Purity:Above95% Package:1KG;66USD
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CAS:50-04-4
Purity:99% Package:100g ,1KG ,5KG 25KG
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Products Intro: Product Name:Cortisone acetate
CAS:50-04-4
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Products Intro: Product Name:Cortisone acetate
CAS:50-04-4
Purity:as in COA Package:as customers' requirements
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Products Intro: Product Name:Cortisone acetate
CAS:50-04-4
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Cortisone acetate manufacturers

  • Cortisone acetate
  • $66.00 / KG
  • 2022-01-06
  • CAS:50-04-4
  • Min. Order: 1KG
  • Purity: Above95%
  • Supply Ability: Weekly supply of 100KG
  • Cortisone acetate
  • $66.00 / KG
  • 2022-01-06
  • CAS:50-04-4
  • Min. Order: 1KG
  • Purity: Above96%
  • Supply Ability: Weekly supply of 100KG
  • Cortisone acetate
  • $0.00-0.00 / Kg/Drum
  • 2021-09-29
  • CAS:50-04-4
  • Min. Order: 1KG
  • Purity: 98%min
  • Supply Ability: 100kg
Cortisone acetate Basic information
Product Name:Cortisone acetate
Synonyms:11,20-trione,17,21-dihydroxy-pregn-4-ene-21-acetate;11-dehydro-17-hydroxycorticosterone-21-acetate;11-dehydro-17-hydroxycorticosteroneacetate;17,21-dihydroxypregn-4-ene-3,11,20-trioneacetate;4-PREGNEN-17ALPHA,21-DIOL-3,11,20-TRIONE ACETATE;4-PREGNEN-17,21-DIOL-3,11,20-TRIONE 21-ACETATE;4-PREGNENE-17ALPHA,21-DIOL-3,11,20-TRIONE 21-ACETATE;17ALPHA,21-DIHYDROXY-4-PREGNENE-3,11,20-TRIONE 21-ACETATE
CAS:50-04-4
MF:C23H30O6
MW:402.48
EINECS:200-006-5
Product Categories:Biochemistry;Hydroxyketosteroids;Steroids;CORTONE;Hormone Drugs;Inhibitors
Mol File:50-04-4.mol
Cortisone acetate Structure
Cortisone acetate Chemical Properties
Melting point 237-240 °C(lit.)
Boiling point 577.3±50.0 °C(Predicted)
alpha D25 +164° (c = 0.5 in acetone); D25 +208 to +217° (dioxane)
density 1.26±0.1 g/cm3(Predicted)
refractive index 212 ° (C=1, MeOH)
storage temp. 2-8°C
solubility Practically insoluble in water, freely soluble in methylene chloride, soluble in dioxan, sparingly soluble in acetone, slightly soluble in ethanol (96 per cent) and in methanol.
form neat
pka12.32±0.60(Predicted)
Water Solubility 19mg/L(25 ºC)
Merck 14,2539
BRN 2067543
Stability:Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference50-04-4(CAS DataBase Reference)
EPA Substance Registry SystemCortisone acetate (50-04-4)
Safety Information
Safety Statements 22-36/37-24/25
WGK Germany 3
RTECS GM9140000
HS Code 32041200
MSDS Information
ProviderLanguage
SigmaAldrich English
Cortisone acetate Usage And Synthesis
DescriptionCortisone acetate is a synthetic glucocorticoid with anti-inflammatory properties. It decreases the size of Bacillus Calmette-Guérin (BCG) vaccine-induced dermal lesions and tuberculin reactions in rabbits when administered at 2 mg/kg on alternate days over the course of 46 days. It also reduces the number and percentage of activated lesion-infiltrating mononuclear cells and decreases the amount of caseous necrosis and ulceration. Cortisone acetate (2.5 mg/kg per day, s.c.) slows tissue regeneration in a rabbit model of wound healing. It also decreases the number of dexamethasone binding sites on isolated human lymphocytes by 30%. Formulations containing cortisone acetate have been used to relieve inflammation, pruritic manifestations of corticosteroid-responsive dermatoses, and in the treatment of immune and allergic disorders.
Chemical Propertiessolid
OriginatorCortone Acetate,MSD,US,1950
UsesCortisone Acetate (Hydrocortisone Acetate EP Impurity D) is a glucocorticoid. Cortisone Acetate is an antiinflammatory agent. Cortisone Acetate is bioavailable and readily converted to the therapeutically active form, Hydrocotisone (H714615).
UsesCortisone Acetate is a glucocorticoid. Cortisone Acetate is an antiinflammatory agent. Cortisone Acetate is bioavailable and readily converted to the therapeutically active form, Hydrocotisone (H71461 5).
Manufacturing ProcessThe following technique is described in US Patent 2,541,104. A solution of 2.0 g of 3(α)-hydroxy-21-acetoxy-11,20-diketo-pregnane, which can be prepared as described in Helv. Chim. Acta 27, 1287 (1944), is treated in a mixture of 25 cc of alcohol and 6.4 cc of acetic acid at 0°C with 6.0 g of potassium
cyanide. The solution is allowed to warm to room temperature and after 3 hours is diluted with water. The addition of a large volume of water to the alcohol-hydrogen cyanide mixture precipitates a gum which is extracted with chloroform or ethyl acetate. The extract is washed with water, and evaporated to small volume under reduced pressure. The crystalline precipitate (1.3 g) consists of 3(α),20-dihydroxy-20-cyano-21-acetoxy-11-keto-pregnane; dec. 175° to 185°C.
A solution of 0.60 g of chromic acid in 1.2 cc of water and 11 cc of acetic acid is added to a solution containing about 1.2 g of 3(α),20-dihydroxy-20-cyano- 21-acetoxy-11-ketopregnane at room temperature. After 1 hour, water is added and the product, which precipitates, is filtered and recrystallized from ethyl acetate to produce 3,11-diketo-20-hydroxy-20-cyano-21-acetoxypregnane; dec. 214° to 217°C.
0.40 cc of phosphorus oxychloride is added to a solution containing about 950 mg of 3,11-diketo-20-hydroxy-20-cyano-21-acetoxy-pregnane dissolved in 3 cc of pyridine. After standing at room temperature for 24 hours, the solution is poured into water and dilute hydrochloric acid, extracted with benzene and concentrated to dryness. The crude product, after chromatography gives one main constituent, namely δ17-3,11-diketo-20-cyano-21-acetoxy-pregnene; MP 189° to 190°C.
A solution of 1.0 g of δ17-3,11-diketo-20-cyano-21-acetoxy-pregnene in 10 cc of benzene is treated with 1.0 g of osmium tetroxide and 0.43 g of pyridine. After standing at room temperature for 18 hours, the resulting solution is treated successively with 50 cc of alcohol, and with 50 cc of water containing 2.5 g of sodium sulfite. The mixture is stirred for 30 hours, filtered, and the filtrate acidified with 0.5 cc of acetic acid and concentrated to small volume in vacuo. The aqueous suspension is then extracted four times with chloroform, the chloroform extracts are combined, washed with water and concentrated to dryness in vacuo. Recrystallization of the residue from acetone gives 9°C. This compound is then treated with acetic anhydride and pyridine for 15 minutes at room temperature to produce 3,11,20-triketo-17(α)-hydroxy-21-acetoxypregnane or cortisone acetate.
Therapeutic FunctionGlucocorticoid
General DescriptionCortisone acetate, 21-(acetyloxy)-17-hydroxypregn-4-ene-3,11,20-trione, is the 21-acetate of naturally occurring cortisone with good systemicanti-inflammatory activity and low-to-moderate salt-retentionactivity after its in vivo conversion to hydrocortisoneacetate. This conversion is mediated by 11β-hydroxysteroiddehydrogenase. It is used for the entire spectrum of uses discussedpreviously under the heading, “Therapeutic Uses ofAdrenal Cortex Hormones”—collagen diseases, Addisondisease, severe shock, allergic conditions, chronic lymphocyticleukemia, and many other indications. Cortisone acetateis relatively ineffective topically, mainly because itmust be reduced in vivo to hydrocortisone. Its plasma halflifeis only about 30 minutes, compared with 90 minutes to3 hours for hydrocortisone.
Purification MethodsCrystallise -1cortisone-21-acetate from acetone or CHCl3. The UV has 15,800 M-1cm at 238nm in dioxane. [Sarett J Biol Chem 162 601 1946, Beilstein 8 III 4058, 5 IV 3481.]
Tag:Cortisone acetate(50-04-4) Related Product Information
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