(4-氯苯硫基)甲叉二膦酸二钠
中文名称 | (4-氯苯硫基)甲叉二膦酸二钠 |
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中文同义词 | (4-氯苯硫基)甲叉二膦酸二钠;替鲁膦酸二钠;化合物 T13159 |
英文名称 | TILUDRONIC ACID, DISODIUM SALT |
英文同义词 | Disodium (4-chlorophenylthio)methylenediphosphonate;SR-41319B;SKELID;TILUDRONIC ACID, DISODIUM SALT;[[(4-CHLOROPHENYL)THIO]METHYLENE]BIPHOSPHONIC ACID, DISODIUM SALT;[[(4-Chlorophenyl)thio]methylene]biphosphonicAcid,DisodiumSalt,SR-41319B,Skelid;Unii-bh6m93cia0;DisodiuM Tiludronate |
CAS号 | 149845-07-8 |
分子式 | C7H10ClNaO6P2S |
分子量 | 342.6 |
EINECS号 | |
相关类别 | 膦配体;有机磷;Intermediates & Fine Chemicals;Pharmaceuticals;Phosphorylating and Phosphitylating Agents |
Mol文件 | 149845-07-8.mol |
结构式 |
(4-氯苯硫基)甲叉二膦酸二钠 性质
熔点 | >300°C |
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储存条件 | -20°C Freezer |
溶解度 | 甲醇(微溶)、水(微溶) |
形态 | 固体 |
颜色 | 白色至类白色 |
Merck | 14,9441 |
The ability of Tiludronate to inhibit proton transport is 5-fold higher in kidney-derived vesicles (IC 50 =1.1 mM) and 10,000-fold higher in vesicles derived from osteoclasts (IC 50 =466 nM). Tiludronate also potently inhibits proton transport in yeast microsomal preparations (IC 50 =3.5 microM) and inhibits the activity of purified yeast V-ATPase. The inhibition of the osteoclast V-ATPase-mediated proton transport by Tiludronate is rapid, pH-dependent, and reversible.
Tiludronate exerts a dose-dependent inhibitory activity on bone resorption. Tiludronate could act on mature osteoclasts by reducing their capacity to secrete proton into the resorption space and also by favoring their detachment from the bone matrix. Tiludronate is also tested in other models of osteoporosis. In the castrated male rat model, Tiludronate (5-200 mg/kg; p.o.) prevents the decrease in the skeletal mass, assessed physically by measuring the bone weight and density or chemically by determining the calcium and phosphate content.
安全信息
海关编码 | 2931.39.0030 |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/01/16 | D4167 | 替鲁膦酸二钠 Disodium Tiludronate | 149845-07-8 | 25mg | 1405元 |