- 2-PHENYLPROPIONIC ACID
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- $0.00 / 1KG
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2024-08-15
- CAS:492-37-5
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1000KGS
- 2-PHENYLPROPIONIC ACID
-
- $0.00 / 1KG
-
2024-08-15
- CAS:492-37-5
- Min. Order: 0.10000000149011612KG
- Purity: 98%
- Supply Ability: 1000KGS
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| 2-PHENYLPROPIONIC ACID Basic information |
| 2-PHENYLPROPIONIC ACID Chemical Properties |
| 2-PHENYLPROPIONIC ACID Usage And Synthesis |
Chemical Properties | clear pale yellow to yellow liquid | Uses | 2-Phenylpropionic acid is used in the preparation of ibuprofen derivatives for their anti-inflammatory activity. Also used in nucleation inhibitors in Dutch resolution of diastereomers. | Definition | ChEBI: A 2-arylpropionic acid carrying a phenyl group at position 2. It is a metabolite of alpha-methylstyrene (AMS), a volatile hydrocarbon. | Synthesis Reference(s) | Journal of the American Chemical Society, 99, p. 182, 1977 DOI: 10.1021/ja00443a033 The Journal of Organic Chemistry, 51, p. 4354, 1986 DOI: 10.1021/jo00373a005 Tetrahedron Letters, 21, p. 581, 1980 DOI: 10.1016/S0040-4039(01)85562-3 | Synthesis | 2-Phenylpropionic acid is prepared: 1) from Benzyl cyanide by Metbylation with
Methyl iodide and Sodamide to produce alpha-Phenylpropionitrile, from which the
acid is produced by acid hydrolysis. 2) from Acetophenone cyanhydrin with Hydriodic
acid. | Purification Methods | Fractionally distil the acid, or recrystallise it from pet ether (b 40-60o) with strong cooling (see references below). [Beilstein 9 II 348.] |
| 2-PHENYLPROPIONIC ACID Preparation Products And Raw materials |
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