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| | t-Butyl α-Lithiobis(trimethylsilyl)acetate Basic information |
| Product Name: | t-Butyl α-Lithiobis(trimethylsilyl)acetate | | Synonyms: | Acetic acid, bis(trimethylsilyl)-, 1,1-dimethylethyl ester, ion(1-), lithium;t-Butyl a-Lithiobis(trimethylsilyl)acetate;Lithium enolate of t-butyl-bistrimethylsilylacetate;t-Butyl α-Lithiobis(trimethylsilyl)acetate | | CAS: | 62803-13-8 | | MF: | C12H27O2Si2.Li | | MW: | 266.45 | | EINECS: | | | Product Categories: | | | Mol File: | 62803-13-8.mol |  |
| | t-Butyl α-Lithiobis(trimethylsilyl)acetate Chemical Properties |
| | t-Butyl α-Lithiobis(trimethylsilyl)acetate Usage And Synthesis |
| Uses |
T-Butyl a-Lithiobis(trimethylsilyl)acetate reacts with aldehydes to form α-silylated vinyl esters.
| | Synthesis |
Synthesis method of t-Butyl α-Lithiobis(trimethylsilyl)acetate: An approximately 1 M solution in THF is prepared by addition of t-butyl bis(trimethylsilyl)acetate to a 1.0 M solution of Lithium Diisopropylamide maintained at -78 °C. The solution is stirred for 1 h at -78 °C following complete addition.1 A simplified procedure utilizes n-Butyllithium in place of LDA and produces the amine-free reagent in THF/hexane.2
| | Synthesis Reference(s) |
1. Hartzell, S. L.; Rathke, M. W. TL 1976, 2737.
2. Sato, Y.; Takeuchi, S. S 1983, 734.
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| | t-Butyl α-Lithiobis(trimethylsilyl)acetate Preparation Products And Raw materials |
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