恩格林A
| 中文名称 | 恩格林A |
|---|---|
| 中文同义词 | 恩格林A;(1S,2R,5R,6R,7S,8R,10R)-10-(GLYCOLOYLOXY)-8-ISOPROPYL-1,5-DIMETHYL-11-OXATRICYCLO[6.2.1.02,6]UNDEC-7-YL (2E)-3-PHENYLACRYLATE |
| 英文名称 | Englerin A |
| 英文同义词 | Englerin A;Englerin A high purity;(-)-ENGLERIN A;2-Propenoic acid, 3-phenyl-, (1R,3aR,4S,5R,7R,8S,8aR)-decahydro-5-[(2-hydroxyacetyl)oxy]-1,4-dimethyl-7-(1-methylethyl)-4,7-epoxyazulen-8-yl ester, (2E)-;(?)-Englerin A;(1S,2R,5R,6R,7S,8R,10R)-10-(Glycoloyloxy)-8-isopropyl-1,5-dimethyl-11-oxatricyclo[6.2.1.02,6]undec-7-yl(2E)-3-phenylacrylate |
| CAS号 | 1094250-15-3 |
| 分子式 | C26H34O6 |
| 分子量 | 442.54 |
| EINECS号 | |
| 相关类别 | 中药对照品 |
| Mol文件 | 1094250-15-3.mol |
| 结构式 |  |
恩格林A 性质
| 沸点 | 550.3±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.20±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 酸度系数(pKa) | 12.88±0.10(Predicted) |
|
hTRPC4 11.2 nM (EC 50 ) |
hTRPC5 7.6 nM (EC 50 ) |
Englerin A (0.15-2500 nM; 48 h) characteristic concentration-dependent suppresses cells growth of the A-498 cells treated with the control siRNA while has little effect on the growth of cells treated with TRPC4 siRNAs.
Englerin A (0.001nM-10 μM; 48 h) inhibits cells viability in HEK293T cells overexpressing TRPC5.
Englerin A (3 nM; 1-240 s) evokes sustained elevation of the intracellular Ca
2+
concentration within 1 min in HEK 293 cells over-expressing human TRPC4.
Englerin A (0.1-1000 nM; 1-300 s) evokes intracellular Ca
2+
elevations in A498 cells as well with an EC
50
of 10 nM.
Englerin A (5 mg/kg; i.p daily except Sunday) markedly inhibits tumor growth during the 2-week treatment period in mice.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-133168 | Englerin A | 1 mg | 3950元 | |
| 2024/04/30 | HY-133168 | 恩格林A Englerin A | 1094250-15-3 | 5 mg | 9980元 |