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2-((4-(benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl dihydrogen phosphate

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Products Intro: Product Name:GSK2983559 FREE ACID
CAS:1579965-12-0
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CAS:1579965-12-0
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CAS:1579965-12-0
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2-((4-(benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl dihydrogen phosphate manufacturers

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  • $35.00 / 1mg
  • 2024-11-19
  • CAS:1579965-12-0
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  • Purity: 98.61%
  • Supply Ability: 10g
  • GSK2983559 free acid
  • GSK2983559 free acid pictures
  • $35.00 / 1mg
  • 2024-11-19
  • CAS:1579965-12-0
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  • Purity: 98.61%
  • Supply Ability: 10g
2-((4-(benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl dihydrogen phosphate Basic information
Product Name:2-((4-(benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl dihydrogen phosphate
Synonyms:2-((4-(benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl dihydrogen phosphate;Ethanol, 2-[[4-(5-benzothiazolylamino)-6-[(1,1-dimethylethyl)sulfonyl]-7-quinazolinyl]oxy]-, 1-(dihydrogen phosphate);Ethanol,2-[[4-(5-benzothiazolylamino)-6-[(1,1-dimethylethyl)sulfonyl]-7-quinazolinyl]oxy]-,dihydrogenphosphate(ester);GSK2983559 (compound 3);GSK2983559 free acid;inhibit,THP-1 cell,RIP kinase,GSK 2983559,GSK2983559 free acid,Inhibitor,GSK-2983559,RIPK,Receptor-interacting protein kinases,GSK-2983559 free acid,GSK2983559
CAS:1579965-12-0
MF:C21H23N4O7PS2
MW:538.53
EINECS:604-604-1
Product Categories:
Mol File:1579965-12-0.mol
2-((4-(benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl dihydrogen phosphate Structure
2-((4-(benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl dihydrogen phosphate Chemical Properties
Boiling point 823.6±75.0 °C(Predicted)
density 1.537±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: slightly soluble; DMSO: 1 mg/ml; PBS (pH 7.2): 1 mg/ml
form A crystalline solid
pka1.76±0.10(Predicted)
color Light yellow to yellow
Safety Information
MSDS Information
2-((4-(benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl dihydrogen phosphate Usage And Synthesis
UsesGSK2983559 free acid (compound 3) is an orally active and potent receptor interacting protein 2 (RIP2) kinase inhibitor. GSK2983559 free acid can block many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples[1].
in vivo

GSK2983559 (oral gavage; 3 and 10 mg/kg; once) inhibits effectively MDP-induced IL-6 in mouse[2].

Animal Model:C57BL/6 mice (female) injected with MDP (100 μg)[2]
Dosage:3 and 10 mg/kg
Administration:Oral gavage; 3 and 10 mg/kg; once
Result:Suppressed serum IL-6 levels in a dose-dependent manner.
IC 50RIPK2
References[1] Haile PA, et al. Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases. J Med Chem. 2019 Jul 25;62(14):6482-6494. DOI:10.1021/acs.jmedchem.9b00575
[2] Shuwei Wu, et al. Design, synthesis, and structure-activity relationship of novel RIPK2 inhibitors. Bioorg Med Chem Lett. 2022 Sep 2;75:128968. DOI:10.1016/j.bmcl.2022.128968
2-((4-(benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl dihydrogen phosphate Preparation Products And Raw materials
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GSK 2334470 GSK2636771 Benzeneacetamide, α-[[6-(4-amino-1-piperidinyl)-3,5-dicyano-4-ethyl-2-pyridinyl]thio]- GSK778 N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(trifluoromethyl)phenyl]-1,4,5,6-tetrahydro-3-pyridinecarboxamide GSK3008348 GSK2983559 cyclopentyl 2-cyclohexyl-2-((6-(3-(hydroxyamino)-3-oxopropyl)pyridin-3-yl)methylamino)acetate GSK3175047 GSK2982772 GSK2894631A GSK-2881078 N-(4-ethylphenyl)-3-(hydroxymethyl)-N-isobutyl-4-((tetrahydro-2H-pyran-4-yl)methoxy)benzenesulfonamide GSK3145095 GSK3039294 L-Lactic dehydrogenase alpha-Lobeline hydrochloride 2'-Deoxyadenosine
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