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| | 1-(2-Amino-5-hydroxyphenyl)propan-1-one Basic information |
| Product Name: | 1-(2-Amino-5-hydroxyphenyl)propan-1-one | | Synonyms: | 1-(2-Amino-5-hydroxyphenyl)propan-1-one;1-propanone,1-(2-amino-5-hydroxyhenyl)-;2-Amino-5-Hydroxy propiophenone;1-Propanone, 1-(2-amino-5-hydroxyphenyl)-;aminoketone;1-(2-Amino-5-hydroxyphenyl)-1-propanone | | CAS: | 35364-15-9 | | MF: | C9H11NO2 | | MW: | 165.19 | | EINECS: | | | Product Categories: | | | Mol File: | 35364-15-9.mol |  |
| | 1-(2-Amino-5-hydroxyphenyl)propan-1-one Chemical Properties |
| Melting point | 144.5-144.9 °C | | Boiling point | 363.9±32.0 °C(Predicted) | | density | 1.195±0.06 g/cm3(Predicted) | | storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere | | solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | 9.35±0.18(Predicted) | | color | Light Yellow to Brown | | Stability: | Hygroscopic |
| | 1-(2-Amino-5-hydroxyphenyl)propan-1-one Usage And Synthesis |
| Uses | 1-(2-Amino-5-hydroxyphenyl)propan-1-one is a useful synthetic intermediate. It is used in the asymmetrical synthesis of (S)-4-ethyl-6,7,8,10- tetrahydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione, a key intermediate for synthesis of irinotecan and other camptothecin analogs. It is also used in the synthesis of E-?ring-?modified (RS)?-?camptothecin analogs as antitumor agents. | | Preparation | Obtained by UV-irradiation of 3-ethyl-2,1-benzisoxazole in 66% sulfuric acid for 90 min at 80–90°
Also prepared from 2-nitro-5-hydroxybenzaldehyde (five steps) or from p-anisidine. |
| | 1-(2-Amino-5-hydroxyphenyl)propan-1-one Preparation Products And Raw materials |
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