BMS-986020

BMS-986020 Suppliers list

Company Name:	ATK CHEMICAL COMPANY LIMITED
Tel:	+undefined-21-51877795
Email:	ivan@atkchemical.com
Products Intro:	CAS:1257213-50-5 Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G

Company Name:	BOC Sciences
Tel:	+1-631-485-4226
Email:	inquiry@bocsci.com
Products Intro:	Product Name:BMS 986020 CAS:1257213-50-5 Purity:>=98% Package:100 mg Remarks:Reach out to us for more information about custom solutions.

Company Name:	career henan chemical co
Tel:	+86-0371-86658258 +8613203830695
Email:	factory@coreychem.com
Products Intro:	Product Name:BMS-986020 CAS: 1257213-50-5 Purity:97%-99% Package:1KG;6.68USD

Company Name:	TargetMol Chemicals Inc.
Tel:	+1-781-999-5354; +17819995354
Email:	marketing@targetmol.com
Products Intro:	Product Name:BMS-986020 CAS:1257213-50-5 Purity:98.82% Package:1mg;47USD\|5mg;76USD\|10mg;122USD Remarks:REAGENT;FOR LABORATORY USE ONLY

Company Name:	HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel:	86-571-88216897,88216896 13588875226
Email:	sales@hzclap.com
Products Intro:	Product Name:BMS-986020 CAS:1257213-50-5 Purity:63299% Package:10kg 25kg 200 kilograms per barrel Remarks:good

BMS-986020 manufacturers

BMS-986020 Basic information

Product Name:	BMS-986020
Synonyms:	BMS-986020;CS-2492;(R)-1-(4'-(3-methyl-4-(((1-phenylethoxy)carbonyl)amino)isoxazol-5-yl)-[1,1'-biphenyl]-4-yl)cyclopropane-1-carboxylic acid;BMS-986020;BMS 986020;BMS986020;1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid;AM152;Cyclopropanecarboxylic acid, 1-[4'-[3-methyl-4-[[[(1R)-1-phenylethoxy]carbonyl]amino]-5-isoxazolyl][1,1'-biphenyl]-4-yl]-;inhibit,idiopathic,AM-152,LPL Receptor,Lysophospholipid Receptor,AM 152,IPF,BMS-986020,fibrosis,pulmonary,BMS 986020,autoradiography,Inhibitor,ARG
CAS:	1257213-50-5
MF:	C29H26N2O5
MW:	482.53
EINECS:
Product Categories:
Mol File:	1257213-50-5.mol

BMS-986020 Chemical Properties

Melting point	174-180°C
Boiling point	664.8±55.0 °C(Predicted)
density	1.309±0.06 g/cm3(Predicted)
storage temp.	-20°C Freezer
solubility	DMSO (Slightly), Methanol (Slightly, Sonicated)
form	Solid
pka	4.19±0.20(Predicted)
color	White to Off-White
InChIKey	GQBRZBHEPUQRPL-LJQANCHMSA-N
SMILES	C1(C2=CC=C(C3=CC=C(C4ON=C(C)C=4NC(O[C@@H](C4=CC=CC=C4)C)=O)C=C3)C=C2)(C(O)=O)CC1

Safety Information

MSDS Information

BMS-986020 Usage And Synthesis

Description	BMS 986020 is a potent G protein-coupled lysophosphatidic acid receptor 1 (LPA₁) antagonist with an IC₅₀ value less than 300 nM for human LPA₁ expressing CHO cells. Formulations containing BMS 986020 are being investigated in clinical trials for efficacy in idiopathic pulmonary fibrosis.
Uses	BMS-?986020 is an LPA-1 antagonist which may be used in the inhibition and treatment of bleomycin-induced pulminary fibrosis.
References	[1] PETER T. W. CHENG*. Discovery of an Oxycyclohexyl Acid Lysophosphatidic Acid Receptor 1 (LPA1) Antagonist BMS-986278 for the Treatment of Pulmonary Fibrotic Diseases[J]. Journal of Medicinal Chemistry, 2021, 64 21: 15549-15581. DOI: 10.1021/acs.jmedchem.1c01256 [2] VEERESA GUDUDURU . Identification of Darmstoff analogs as selective agonists and antagonists of lysophosphatidic acid receptors[J]. Bioorganic & Medicinal Chemistry Letters, 2006, 16 2: Pages 451-456. DOI: 10.1016/j.bmcl.2005.08.096 [3] L. SIVARAMAN . Structure dependence and species sensitivity of in vivo hepatobiliary toxicity with lysophosphatidic acid receptor 1 (LPA1) antagonists[J]. Toxicology and applied pharmacology, 2022, 438: Article 115846. DOI: 10.1016/j.taap.2021.115846 [4] BHAKTA PRASAD GAIRE Ji W C Arjun Sapkota. BMS-986020, a Specific LPA1 Antagonist, Provides Neuroprotection against Ischemic Stroke in Mice.[J]. Antioxidants, 2020, 9 11. DOI: 10.3390/antiox9111097

BMS-986020 Preparation Products And Raw materials

Tag:BMS-986020(1257213-50-5) Related Product Information

BMS-852927 XL-652 BMS-986142 BMS 303141 BMS813160 2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- Insulin-like Growth Factor-1 Receptor Inhibitor PD-L1 inhibitor 1 AC480 (BMS-599626) BMS-986205 1-O-9Z-Octadecenoyl-sn-glyceryl-3-phosphoricacidsodiumsalt (R)-2-(4'-(4-(((1-(2-chlorophenyl)ethoxy)carbonyl)aMino)-3-Methylisoxazol-5-yl)-[1,1'-biphenyl]-4-yl)acetic acid BMS-986278 TC LPA5 4

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