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3-METHYLADENINE

3-METHYLADENINE Suppliers list
Company Name: Nanjing ChemLin Chemical Industry Co., Ltd.
Tel: 025-83697070;product@chemlin.com.cn
Email: product@chemlin.com.cn
Products Intro: CAS:5142-23-4
Purity:97% Package:g-Kg
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +86 21 5161 9050/ 5187 7795
Email: ivan@atkchemical.com
Products Intro: Product Name:NSC 66389,3-MA
CAS:5142-23-4
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: career henan chemical co
Tel: +86-0371-55982848
Email: sales@coreychem.com
Products Intro: Product Name:3-METHYLADENINE
CAS:5142-23-4
Purity:99% Package:1kg;2USD
Company Name: Biochempartner
Tel: 0086-13720134139
Email: candy@biochempartner.com
Products Intro: Product Name:3MA
CAS:5142-23-4
Purity:98% HPLC LCMS Package:10G;20G
Company Name: GIHI CHEMICALS CO.,LIMITED
Tel: 08657186217390
Email: sales@gihichemicals.com
Products Intro: Product Name:3-METHYLADENINE
CAS:5142-23-4
Purity:98% HPLC Package:5g/bag;100g/bag;1kg/bag;5kg/bag;25kg/bag

3-METHYLADENINE manufacturers

  • 3-METHYLADENINE
  • $10.00 / KG
  • 2021-10-12
  • CAS:5142-23-4
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 5tons
  • 3-METHYLADENINE
  • $2.00 / kg
  • 2019-07-06
  • CAS:5142-23-4
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 100kg
3-METHYLADENINE Basic information
Product Name:3-METHYLADENINE
Synonyms:3H-Purin-6-amine, 3-methyl-;3-methyl-3h-purin-6-amin;3-Methyl-3H-purin-6-amine;3-methyl-adenin;Adenine, 3-methyl-;3-METHYLADENINE;3-methyl-3H-adenine;6-AMINO-3-METHYLPURINE
CAS:5142-23-4
MF:C6H7N5
MW:149.15
EINECS:225-908-6
Product Categories:Akt;mTOR;Amines;Bases & Related Reagents;Heterocycles;PI3K;Inhibitors;Nucleotides
Mol File:5142-23-4.mol
3-METHYLADENINE Structure
3-METHYLADENINE Chemical Properties
Melting point ~300 °C (dec.)(lit.)
Boiling point 240℃
density 1.60
refractive index 1.8070 (estimate)
Fp 99℃
storage temp. Keep in dark place,Sealed in dry,Room Temperature
form Powder
pka6.77±0.20(Predicted)
color White
BRN 146087
Safety Information
Hazard Codes Xn
Risk Statements 22
Safety Statements 24/25
WGK Germany 3
RTECS AU6520000
HS Code 29335990
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
3-METHYLADENINE Usage And Synthesis
DescriptionAutophagy is a multi-step process that involves the degradation and digestion of intracellular components by the lysosome. This process allows cells to efficiently mobilize and recycle cellular constituents, and also prevents the accumulation of damaged organelles, misfolded proteins, and invading microorganisms. mTOR, whose activation is controlled by phosphoinositide 3-kinase (PI3K), is a key regulator of autophagy. 3-Methyladenine (3-MA) is a specific inhibitor of PI3K activity and one of the most widely used inhibitors of the initial phase of the autophagic process: the sequestering of cytoplasmic material by the lysosome. At 5 mM, 3-MA inhibits protein degradation in rat hepatocytes by 65%. 3-MA has been shown to block class I, class II, and class III PI3Ks, including some downstream targets, and to suppress the invasion of highly metastatic human fibrosarcoma HT1080 cells at 10 mM.
Chemical PropertiesWhite powder
Uses3-Methyladenine (3-MA) inhibits autophagy by blocking autophagosome formation via the inhibition of type III Phosphatidylinositol 3-kinases (PI-3K). For use as an autophagy inhibitor, 3-MA is typically used at a concentration of 5 mM.
UsesA multi-use inhibitor that protects cerebellar granule cells from apoptosis.
UsesA synthetic intermediate and a cell-permeable autophagic sequestration blocker that protects cerebellar granule cells from apoptosis post serum/potassium deprivation
DefinitionChEBI: A methyladenine that is adenine substituted with a methyl group at position N-3.
Tag:3-METHYLADENINE(5142-23-4) Related Product Information
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