lumateperone (Tosylate) manufacturers
- Lumateperone Tosylate
-
- $0.00 / 1gram
-
2024-03-15
- CAS:1187020-80-9
- Min. Order: 5gram
- Purity: 99.99%
- Supply Ability: 1Tons/year
- lumateperone (Tosylate)
-
- $16000.00 / 1000g
-
2023-11-01
- CAS:1187020-80-9
- Min. Order: 1g
- Purity: 99.0%min singleimpurity 0.5%max
- Supply Ability: 50KG
- lumateperone (Tosylate)
-
- $1.10 / 1g
-
2022-03-11
- CAS:1187020-80-9
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons
|
| | lumateperone (Tosylate) Basic information |
| Product Name: | lumateperone (Tosylate) | | Synonyms: | 1-(4-Fluorophenyl)-4-[(6bR,10aS)-2,3,6b,9,10,10a-hexahydro-3-methyl-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl]-1-butanone 4-methylbenzenesulfonate (1:1);Lumateperone(ITI-007);lumateperone (Tosylate);ITI 007;ITI-007;ITI 007;ITI007;LUMATEPERONE;1187020-80-9;ITI-722; ITI722; ITI 722; ITI-007; ITI007; ITI 007; LUMATEPERONE, CAPLYTA,;lumateperone (Tosylate) ISO 9001：2015 REACH;Lumateperone toluenesulfonic acid (PTSA salt) | | CAS: | 1187020-80-9 | | MF: | C31H36FN3O4S | | MW: | 565.7 | | EINECS: | | | Product Categories: | | | Mol File: | 1187020-80-9.mol |  |
| | lumateperone (Tosylate) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:7): 0.12 mg/ml; DMSO: 10 mg/ml; Ethanol: 1 mg/ml | | form | A solid | | InChIKey | LHAPOGAFBLSJJQ-HXLBOWIHNA-N | | SMILES | S(C1C=CC(C)=CC=1)(O)(=O)=O.CN1CCN2[C@@]3([H])CCN(CCCC(C4C=CC(F)=CC=4)=O)C[C@@]3([H])C3=CC=CC1=C32 |&1:16,34,r| |
| | lumateperone (Tosylate) Usage And Synthesis |
| Uses |
lumateperone (Tosylate) is a new second-generation antipsychotic indicated for treating schizophrenia that can potentially alleviate positive and negative symptoms. This drug interacts with dopamine, serotonin, and glutamate, making it unique compared to other antipsychotics. Its highly selective nature for D2R receptors in specific brain regions decreases unfavorable adverse effects and makes it a safer drug[1].
| | Biochem/physiol Actions | Lumateperone tosylate (ITI-007) is an orally active, potent 5-HT2A antagonist, postsynaptic D2 antagonist, and serotonin transporter SERT inhibitor (Ki = 0.5, 32, 62 nM, respectively) with in vivo antipsychotic efficacy and no effect toward receptors associated with cognitive and metabolic side effects of antipsychotic drugs (e.g., H1, 5-HT2C, muscarinic). ITI-007 blocks DOI-induced headtwitch (ID50 = 0.09 mg/kg, po.) and D-AMPH-induced hyperlocomotion in mice (ID50 = 0.95 mg/kg, po.), while also acting as a partial agonist at presynaptic striatal D2 receptors. | | References | [1] Kunal Maini. “Lumateperone tosylate, A Selective and Concurrent Modulator of Serotonin, Dopamine, and Glutamate, in the Treatment of Schizophrenia.” Health Psychology Research (2021): 24932.
|
| | lumateperone (Tosylate) Preparation Products And Raw materials |
|