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IMR-1A

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IMR-1A Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:IMR-1A
CAS:331862-41-0
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: BOC Sciences
Tel: +1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:IMR-1A
CAS:331862-41-0
Package:25mg Remarks:BOC Sciences also provides custom synthesis services for IMR-1A.
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:IMR-1A
CAS:331862-41-0
Purity:99.06% Package:1mg;68USD|5mg;163USD|10mg;263USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:IMR-1A
CAS:331862-41-0
Purity:98% Package:5mg Remarks:V19758
Company Name: TargetMol Chemicals Inc.
Tel:
Email: support@targetmol.com
Products Intro: Product Name:IMR-1A
CAS:331862-41-0
Package:1 mg；10 mg；100 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY

IMR-1A manufacturers

  • IMR-1A
  • IMR-1A pictures
  • $68.00 / 1mg
  • 2024-11-07
  • CAS:331862-41-0
  • Min. Order:
  • Purity: 99.06%
  • Supply Ability: 10g
IMR-1A Basic information
Product Name:IMR-1A
Synonyms:IMR-1A;IMR1A;IMR 1A;IMR-1A;IMR-1A, >98%;Acetic acid, 2-[2-methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]-;2-(2-Methoxy-4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetic acid;Notch,Inhibitor,inhibit,IMR1A,IMR-1A,IMR 1A,Drug Metabolite
CAS:331862-41-0
MF:C13H11NO5S2
MW:325.36
EINECS:
Product Categories:
Mol File:331862-41-0.mol
IMR-1A Structure
IMR-1A Chemical Properties
density 1.55±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility DMSO:4.0(Max Conc. mg/mL);12.29(Max Conc. mM)
Water:1.0(Max Conc. mg/mL);3.07(Max Conc. mM)
pka3.10±0.10(Predicted)
form Solid
color Light yellow to yellow
Safety Information
MSDS Information
IMR-1A Usage And Synthesis
Biological ActivityIMR-1A is a potent inhibitor of Notch with IC50 of 0.5 μM and Kd of 2.9 μM. It has antitumor activity.
in vivo

IMR-1A (2 mg/kg (iv) and 100 mg/kg (ip)) exhibits low systematic plasma clearance (CL = 7 mL/min/kg) with terminal elimination half-life (T1/ 2) of 2.22 h following a single iv administration. The normal liver blood flow in mice is 90 mL/min/kg and the Vss (volume of distribution) is ~4-fold. Plasma concentrations is quantifiable up to 24 h with Tmax of 0.50 h after ip administration.

< td class="col1 fwb"> Administration:
Animal Model: Male C57 BL/6 mice
Dosage: 2 mg/kg (iv) and 100 mg/kg (ip)
Iv and ip
Result: Exhibited low systematic plasma clearance (CL = 7 mL/min/kg) with terminal elimination half-life (T1/2) of 2.22 h following a single iv administration and plasma concentrations is quantifiable up to 24 h with Tmax of 0.50 h after ip administration.
target< /table>
TargetValue
Notch
(Cell-free assay)		 0.5 μM
Notch
(Cell-free assay)		 2.9 μM(Kd)
IMR-1A Preparation Products And Raw materials
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