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| 2-MERCAPTO-5-METHOXYBENZIMIDAZOLE Basic information | Description |
| 2-MERCAPTO-5-METHOXYBENZIMIDAZOLE Chemical Properties |
Melting point | 261-263 °C(lit.) | Boiling point | 309.4±44.0 °C(Predicted) | density | 1.2425 (rough estimate) | vapor pressure | 0.001Pa at 25℃ | refractive index | 1.5690 (estimate) | storage temp. | 2-8°C | solubility | DMSO (Slightly), Methanol (Sparingly) | pka | 10.13±0.30(Predicted) | form | Powder | color | Off-white to light yellow-brown | Water Solubility | insoluble | Sensitive | Air Sensitive | BRN | 3605123 | LogP | 1.52-2.399 | CAS DataBase Reference | 37052-78-1(CAS DataBase Reference) |
Hazard Codes | Xi,Xn | Risk Statements | 36/37/38-37-22 | Safety Statements | 26-36 | WGK Germany | 3 | HazardClass | IRRITANT | HS Code | 29332900 |
| 2-MERCAPTO-5-METHOXYBENZIMIDAZOLE Usage And Synthesis |
Description | 2-Mercapto-5-methoxybenzimidazole is used in the preparation of COX-2 inhibitors. It is also employed in the preparation of compounds such as 5-methoxy-2[[(4-methoxy-3, 5-dimethyl-2-pyridinyl) methyl] sulfonyl]-1H-benzimidazole, 5-methoxy-2[[(4-methoxy-3, 5-dimethylpyridin-2-yl-1-oxide) methyl] sulfonyl]-1H-benzimidazole as well as tris[μ-1,2-bis(diphenylphosphino)ethane]-1:2κ2P:P′;1:3κ2P:P′;2:3κ2P:P′-di-μ-bromido-1:2κ4Br:Br-bromido-3κBr-tricopper(I) acetone hemisolvate. Furthermore, it acts as a hetercocyclic building block and serves as an intermediate of drug omeprazole1. Finally, it acts as an intermediate for manufacture of the anti-ulcer drug Omeprazole.
| Chemical Properties | off-white to light yellowish-brown powder | Uses | 5-Methoxy-2-benzimidazolethiol may be used in the preparation of compounds present as contaminants in omeprazole, such as 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfonyl]-1H-benzimidazole and 5-methoxy-2-[[(4-methoxy-3,5-dimethylpyridin-2-yl-1-oxide)methyl]sulfonyl]-1H-benzimidazole. It may be used in the synthesis of tris[μ-1,2-bis(diphenylphosphino)ethane]-1:2κ2P:P′;1:3κ2P:P′;2:3κ2P:P′-di-μ-bromido-1:2κ4Br:Br-bromido-3κBr-tricopper(I) acetone hemisolvate. | Uses | Reagent used in the synthesis of COX-2 inhibitors | Uses | 2-Mercapto-5-methoxybenzimidazole is used in the preparation of COX-2 inhibitors. It is also employed in the preparation of compounds such as 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfonyl]-1H-benzimidazole and 5-methoxy-2-[[(4-methoxy-3,5-dimethylpyridin-2-yl-1-oxide)methyl]sulfonyl]-1H-benzimidazole. Further, it acts as a hetercocyclic building block and serves as an intermediate of drug omeprazole. | General Description | Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards | Flammability and Explosibility | Not classified |
| 2-MERCAPTO-5-METHOXYBENZIMIDAZOLE Preparation Products And Raw materials |
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