UNC3866 manufacturers
- UNC3866
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- $7.00 / 1KG
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2020-02-14
- CAS: 1872382-47-2
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 100KG
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| | UNC3866 Basic information |
| Product Name: | UNC3866 | | Synonyms: | UNC3866;N-[4-(1,1-Dimethylethyl)benzoyl]-L-phenylalanyl-L-alanyl-L-leucyl-N6,N6-diethyl-L-lysyl-L-serine methyl ester;CS-2491;UNC 3866;UNC-3866;(3S,6S,9S,12S,15S)-Methyl 3-benzyl-1-(4-(tert-butyl)phenyl)-12-(4-(diethylamino)butyl)-15-(hydroxymethyl)-9-isobutyl-6-methyl-1,4,7,10,13-pentaoxo-2,5,8,11,14-pentaazahexadecan-16-oate;L-Serine, N-[4-(1,1-dimethylethyl)benzoyl]-L-phenylalanyl-L-alanyl-L-leucyl-N6,N6-diethyl-L-lysyl-, methyl ester;UNC3866,inhibit,Histone Methyltransferase,UNC-3866,Inhibitor,UNC 3866 | | CAS: | 1872382-47-2 | | MF: | C43H66N6O8 | | MW: | 795.02 | | EINECS: | | | Product Categories: | | | Mol File: | 1872382-47-2.mol |  |
| | UNC3866 Chemical Properties |
| Boiling point | 1034.5±65.0 °C(Predicted) | | density | 1.129±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | Soluble in DMSO | | form | A crystalline solid | | pka | 13.39±0.46(Predicted) |
| | UNC3866 Usage And Synthesis |
| Description | UNC3866 is an inhibitor of chromobox homolog 7 (CBX7; Kd = 97 nM). It also binds to CBX4 (Kd = 94 nM) but is greater than 6-fold selective over CBX2, 6, and 8 and the chromodomain Y family (CDY) chromodomains CDY1, L1b, and L2 (Kds = 0.61-6.3 μM). UNC3866 pretreatment (30 μM) of PC3 lysates completely inhibits chemiprecipitation of CBX7. It induces a senescent-like morphology and reduces growth of PC3 cells with an EC50 value of 7.6 μM. | | Uses | Polycomb group proteins (CBX4, CBX7) regulate cell fate decisions during embryogenesis. N-?[4-?(1,?1-Dimethylethyl)?benzoyl]?-?L-?phenylalanyl-?L-?alanyl-?L-?leucyl-?N6,?N6-?diethyl-?L-?lysyl-?L-serine Methyl Ester is a selective antagonist of CBX4 and CBX7 chromodomains. It also inhibits prostate cell proliferation. |
| | UNC3866 Preparation Products And Raw materials |
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