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| | 5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL Basic information |
| | 5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL Chemical Properties |
| Melting point | 168-170°C | | Boiling point | 515.3±38.0 °C(Predicted) | | density | 1.03±0.1 g/cm3(Predicted) | | storage temp. | Refrigerator | | solubility | Soluble in DMSO or in Ethanol. | | form | solid | | pka | 14.11±0.70(Predicted) | | color | White or pale yellow | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| | 5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL Usage And Synthesis |
| Description | 7α-Hydroxycholesterol (566-26-7) is a metabolite resulting from the action of cholesterol 7α-hydroxylase on cholesterol. 7α-Hydroxycholesterol is the first intermediate and a rate limiting step in the major pathway for bile acid synthesis in humans.??A pro-inflammatory mediator which upregulates production of CCL2 and MMP9 in macrophages and may promote progression of atherosclerosis.2,3?Possible biomarker for cellular lipid peroxidation.4 | | Chemical Properties | White Solid | | Uses | Secondary metabolite of Cholesterol. | | Definition | ChEBI: The 7alpha-hydroxy derivative of cholesterol. | | References | 1) Duane and Javitt (2002),?Conversion of 7 alpha-hydroxycholesterol to bile acid in human subjects: is there an alternate pathway favoring cholic acid synthesis?; J. Lab. Clin. Med.,?139?109
2) Kim?et al.?(2015)?7α-Hydroxycholesterol induces inflammation by enhancing production of chemokine (C-C motif) ligand 2; Biochem. Biophys. Res. Commun.,?467?879
3) Kim?et al.?(2014)?27-Hydroxycholesterol and 7alpha-hydroxycholesterol trigger a sequence of events leading to migration of CCR5-expressing Th1 lymphocytes; Toxicol. Appl. Pharmacol.,?274?462
4) Saito and Noguchi (2014)?7-Hydroxycholesterol as a possible biomarker of cellular lipid peroxidation: difference between cellular and plasma lipid peroxidation; Biochem. Biophys. Res. Commun.,?446?741 |
| | 5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL Preparation Products And Raw materials |
| Preparation Products | (7R,8S,9S,10R,13R,14S,17R)-7-hydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one-->7-KETOCHOLESTEROL |
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