| Company Name: |
Guangzhou Isun Pharmaceutical Co., Ltd
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| Tel: |
020-39119399 18927568969 |
| Email: |
isunpharm@qq.com |
| Products Intro: |
Product Name:Pseudocoptisine chloride
CAS:30044-78-1
Purity:98.0% Package:1G; 25G; 1KG; 25KG
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| | Pseudocoptisine chloride Basic information |
| Product Name: | Pseudocoptisine chloride | | Synonyms: | Pseudocoptisine chloride;Isocoptisine chloride;Isocoptisine,anti-amnestic,Pseudocoptisine chloride,cytokines,anti-inflammatory,Pseudocoptisine,pro-inflammatory,RAW 264.7,Cholinesterase (ChE),inhibit,Inhibitor | | CAS: | 30044-78-1 | | MF: | C19H14ClNO4 | | MW: | 355.77 | | EINECS: | | | Product Categories: | | | Mol File: | 30044-78-1.mol |  |
| | Pseudocoptisine chloride Chemical Properties |
| storage temp. | Store at -20°C |
| | Pseudocoptisine chloride Usage And Synthesis |
| Biological Activity | Pseudocoptisine (Isocoptisine) chloride is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber. Pseudocoptisine chloride inhibits acetylcholinesterase (AChE) activity with an IC50 of 12.8 μM. Anti-inflammatory and anti-amnestic effects. | | in vitro | Pseudocoptisine (0, 60, 90 μM; 1 hour) dose-dependently inhibited LPS-induced NO production in RAW264.7 cells.
Pseudocoptisine (30-90 μM; 1 hour; RAW264.7 cells) significantly reduces the LPS-induced TNF-α and IL-6 production and their mRNA expressions.
Pseudocoptisine acetate reduces levels of the pro-inflammatory mediators, such as, iNOS, COX-2, TNF-alpha, and IL-6 through the inhibition of NF-kappaB activation via the suppression of ERK and p38 phosphorylation in RAW 264.7 cells. | | in vivo | The anti-amnesic activities of Pseudocoptisine in mice on the learning and memory impairments induced by scopolamine (1.0 mg/kg, ip) are examined. Pseudocoptisine (2.0 mg/kg, po) significantly reverses cognitive impairments in mice by passive avoidance test. |
| | Pseudocoptisine chloride Preparation Products And Raw materials |
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