| Company Name: |
Chongqing Chemieliva Pharmaceutical Co., Ltd.
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18696571988 |
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amy.lei@chemieliva.com |
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Product Name:Piperidine, 4-[[3-(1,3-benzodioxol-5-yl)-1,2,4-oxadiazol-5-yl]methyl]-1-cyclobutyl-
CAS:1448422-61-4
Purity:95%-97%
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| Company Name: |
Cool Pharm, Ltd
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021-58581007 18019463053 |
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sales@coolpharm.com |
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Product Name:3-(Benzo[d][1,3]dioxol-5-yl)-5-((1-cyclobutylpiperidin-4-yl)methyl)-1,2,4-oxadiazole
CAS:1448422-61-4
Purity:95.0% Package:10g;25g;100g;500g;1kg;5kg;10kg
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| Company Name: |
Shanghai Jieshikai Biotechnology Co. , Ltd.
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| Tel: |
021-57520305 13795461237 |
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zhuruyan@jskchem.com |
| Products Intro: |
Product Name:3-(Benzo[d][1,3]dioxol-5-yl)-5-((1-cyclobutylpiperidin-4-yl)methyl)-1,2,4-oxadiazole
CAS:1448422-61-4
Purity:95% Package:100mg;250mg;1g
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
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marketing@targetmol.cn |
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Product Name:H3R antagonist 1
CAS:1448422-61-4
Package:50mg/RMB 13800
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| Company Name: |
Biorbyt Ltd.
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| Tel: |
+44 (0)1223 859 353 |
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info@biorbyt.com |
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Product Name:H3R antagonist 1
CAS:1448422-61-4
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| | Piperidine, 4-[[3-(1,3-benzodioxol-5-yl)-1,2,4-oxadiazol-5-yl]methyl]-1-cyclobutyl- Basic information |
| Product Name: | Piperidine, 4-[[3-(1,3-benzodioxol-5-yl)-1,2,4-oxadiazol-5-yl]methyl]-1-cyclobutyl- | | Synonyms: | Piperidine, 4-[[3-(1,3-benzodioxol-5-yl)-1,2,4-oxadiazol-5-yl]methyl]-1-cyclobutyl-;3-(Benzo[d][1,3]dioxol-5-yl)-5-((1-cyclobutylpiperidin-4-yl)methyl)-1,2,4-oxadiazole;H3R antagonist 1 | | CAS: | 1448422-61-4 | | MF: | C19H23N3O3 | | MW: | 341.4 | | EINECS: | | | Product Categories: | | | Mol File: | 1448422-61-4.mol | ![Piperidine, 4-[[3-(1,3-benzodioxol-5-yl)-1,2,4-oxadiazol-5-yl]methyl]-1-cyclobutyl- Structure](CAS/20180601/GIF/1448422-61-4.gif) |
| | Piperidine, 4-[[3-(1,3-benzodioxol-5-yl)-1,2,4-oxadiazol-5-yl]methyl]-1-cyclobutyl- Chemical Properties |
| Boiling point | 490.8±55.0 °C(Predicted) | | density | 1.282±0.06 g/cm3(Predicted) | | pka | 9.53±0.40(Predicted) | | form | Solid | | color | White to off-white |
| | Piperidine, 4-[[3-(1,3-benzodioxol-5-yl)-1,2,4-oxadiazol-5-yl]methyl]-1-cyclobutyl- Usage And Synthesis |
| Uses | H3R-IN-1 is a histamine receptor 3 (H3R) inverse agonist extracted from patent WO2013107336A1, compound example 2. | | in vivo | The ability of H3R-IN-1 to enhance in vivo remyelination is determined with the Cuprizone/Rapamycin-induced demyelination model. Mice are treated with Cuprizone diet combined with intraperitoneal injections of Rapamycin for 5 weeks followed by 9 days of compound administration. Cuprizone diet plus intraperitoneal injections of Rapamycin induced severe demyelination in both corpus callosum and cortex and treatment with H3R-IN-1 (30 mg/kg, 9 days) significantly increases density of myelin specific Black-gold II staining in the lesion of corpus callosum and cortex in forebrain, compared to vehicle control group[1]. | | References | [1] WANG, Rong, et al. THERAPEUTIC USES. WO2013107336A1. |
| | Piperidine, 4-[[3-(1,3-benzodioxol-5-yl)-1,2,4-oxadiazol-5-yl]methyl]-1-cyclobutyl- Preparation Products And Raw materials |
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