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Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136 |
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Sales@ATKchemical.com |
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Product Name:3-{5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrrol-2-yl}propanoic acid
CAS:683808-78-8
Purity:98 Package:1G,5G,10G,50G,100G,500G
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3-{5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrrol-2-yl}propanoic acid manufacturers
- Poloppin
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- $65.00 / 1mg
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2024-10-28
- CAS:683808-78-8
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | 3-{5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrrol-2-yl}propanoic acid Basic information |
| | 3-{5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrrol-2-yl}propanoic acid Chemical Properties |
| Boiling point | 536.7±50.0 °C(Predicted) | | density | 1.45±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: 2mg/mL, clear | | pka | 4.62±0.10(Predicted) | | form | powder | | color | white to beige |
| | 3-{5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrrol-2-yl}propanoic acid Usage And Synthesis |
| Description | Poloppin is a modulator of protein-protein interactions of the mitotic polo-like kinases. It acts by targeting mutant KRAS, working synergistically with Crizotinib, an inhibitor of the c-MET receptor, against mutant KRAS-expressing cancer cells. | | Uses | Poloppin is a potent, cell penetrant inhibitor of the mitotic Polo-like kinase (PLK) (IC50=26.9?μM) and prevents the protein-protein interaction via the Polo-box domain (PBD) (Kd= 29.5?μM). Poloppin selectively kills cells expressing mutant KRAS, enhancing death in mitosis.?Poloppin is used for the study of KRAS-mutant cancers as single agents, or in combination with c-MET inhibitors[1]. | | References | [1] Ana J Narvaez, et al. Modulating Protein-Protein Interactions of the Mitotic Polo-like Kinases to Target Mutant KRAS. Cell Chem Biol. 2017 Aug 17;24(8):1017-1028.e7. DOI:10.1016/j.chembiol.2017.07.009 |
| | 3-{5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrrol-2-yl}propanoic acid Preparation Products And Raw materials |
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