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Sildenafil citrate

Sildenafil citrate Suppliers list
Company Name: Beijing Yibai Biotechnology Co., Ltd
Tel: 0086-182-6772-3597
Products Intro: Product Name:Sildenafil citrate
Purity:99%+ Package:1g;0USD|1KG;0USD|10KG;0USD|25KG
Company Name: Cangzhou Wanyou New Material Technology Co.,Ltd
Tel: 18631714998
Products Intro: Product Name:Sildenafil citrate
Purity:99% Package:1g;1USD
Company Name: Shanghai Longyu Biotechnology Co., Ltd.
Tel: +8615821988213
Products Intro: Product Name:sildenafil citrate
Purity:99% Package:1g;1USD Remarks:Accept Paypal/western union/bitcoin/money gram/alibaba trade assurance
Company Name: Shenzhen Excellent Biotech Co., Ltd.
Tel: 13480692018
Products Intro: Product Name:Sildenafil citrate
Purity:0.99 Package:1KG;5KG;25KG Remarks:Large package please cotact us QQ:3001349363
Company Name: Hebei Bonster Technology Co.,Limited
Tel: +86-13315996897
Products Intro: Product Name:Sildenafil Citrate(Viagra powder)
Purity:0.99 Package:1g;10g;50g;100g;1kg;5KG;25kg

Lastest Price from Sildenafil citrate manufacturers

  • Sildenafil citrate
  • US $0.00-0.00 / KG
  • 2020-07-22
  • CAS:171599-83-0
  • Min. Order: 1g
  • Purity: 99%+
  • Supply Ability: 500kg/month
Sildenafil citrate Basic information
Product Name:Sildenafil citrate
Synonyms:99% high purity sex powder sildenafil and sildenafile citrate;5-(2-ETHOXY PHENYL)-1-METHYL-3-N-PROPYL- 1, 6-DIHYDRO-7H-PYRAZOLO-4,3-D-PYRIMIDIN E-ONE;Sildenafil citrate - Viagra | UK 92480;Sildenafi;din-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methyl-,2-hydroxy-1,2,3-propanetricarbo;piperazine,1-((3-(4,7-dihydro-1-methyl-7-oxo-3-propyl-1h-pyrazolo(4,3-d)pyrimi;piperazine,1-((3-(4,7-dihydro-1-methyl-7-oxo-3-propyl-1h-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methyl-,2-hydroxy-1,2,3-propanetricarboxylate(1:1);uk92480-10
Product Categories:Viagra, Revatio;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Sildenafil;Pfizer compounds;Inhibitor;organic interme
Mol File:171599-83-0.mol
Sildenafil citrate Structure
Sildenafil citrate Chemical Properties
Melting point 187-189°C
storage temp. Desiccate at RT
solubility DMSO: >20mg/mL
form white powder
Water Solubility 3.488g/L(temperature not stated)
Merck 14,8489
Stability:Store in Freezer
CAS DataBase Reference171599-83-0(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 36
WGK Germany 3
RTECS TL4284390
HS Code 2933595960
MSDS Information
Sildenafil citrate Usage And Synthesis
Chemical PropertiesWhite Solid
UsesAn orally active selective type 5 cGMP phosphodiesterase inhibitor
UsesEnzyme inhibitor
DefinitionChEBI: The citrate salt of sildenafil.
Brand nameViagra (Pfizer).
Biological ActivityOrally active, potent inhibitor of phosphodiesterase 5 (PDE5) (IC 50 = 4 nM). Enhances nitric oxide-dependent relaxation of human corpus cavernosum in vitro .
Safety ProfileA poison by ingestion. Human systemic effects. When heated to decomposition it emits toxic vapors of NOx and SOx.
Veterinary Drugs and TreatmentsSildenafil may be of benefit in the adjunctive treatment of pulmonary hypertension in small animals.
In humans, sildenafil is indicated for erectile dysfunction or pulmonary hypertension.
structure and hydrogen bondingSildenafil citrate (SC) has been widely used for the treatment of erectile disorder. A detailed study concerning solid-state structure of this compound is very important for understanding enzyme (PDE5)-inhibitor (sildenafil) interaction. It is also of interest to determine sildenafil’s protonation sites, as they may be responsible for its binding to the phosphodiesterase acidic amino acids.
Sildenafil citrate (Viagra)  and sildenafil base in pure form were characterized by 1H, 13C, 15N NMR spectroscopy in solution, solid-state, and pharmaceutical dosage forms.42 The analysis of chemical shifts showed that: (i) N6-H forms intramolecular hydrogen bonds, (ii) N25 is protonated in the salt, and (iii) intermolecular OH. . .N hydrogen bonds involving N2 and N4 are present in the solid sildenafil citrate. The 13C CPMAS spectra of the tablets containing different amounts of sildenafil citrate were recorded and showed that chemical shifts of sildenafil citrate in pure form and in pharmaceutical dosage forms are the same. SC is easily detected in the pharmaceutical dosage forms since only two of its carbon resonances (OCH2 and quaternary carbon of the citrate anion) fall into carbohydrate-type region of the excipient.
Solid-state 13C and 15N MAS NMR have recently been used to investigate how water interacts with SC.43 When the humidity is altered, the water concentration in the solid compound changes but does not reach a stoichiometric (e.g., 1:1) ratio to form a true hydrate. Only one set of 15N and 13C signals was observed for each humidity level indicating that water incorporated into the crystal lattice of SC is very mobile and exchanges rapidly between various sites. The 13C data showed the formation of a hydrogen bond between water molecule and one carbonyl of the citrate anion. The spectra also show that the water content affects the conformation of the propyl group. Additionally, 15N dipolar dephasing (DD) experiments confirmed that the sildenafil molecule is only protonated in the piperazine ring.
Sildenafil citrate Preparation Products And Raw materials
Tag:Sildenafil citrate(171599-83-0) Related Product Information
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