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Diethyl malate

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Diethyl malate Basic information
Product Name:Diethyl malate
Synonyms:2-hydroxy-butanedioicaciddiethylester;Butanedioicacid,hydroxy-,diethylester;hydroxy-butanedioicacidiethylester;FEMA 2374;ETHYL-DL-MALATE;DIETHYL MALATE;DIETHYL DL-MALATE;DL-MALIC ACID DIETHYL ESTER
CAS:7554-12-3
MF:C8H14O5
MW:190.19
EINECS:231-444-5
Product Categories:
Mol File:7554-12-3.mol
Diethyl malate Structure
Diethyl malate Chemical Properties
Boiling point 122-124 °C12 mm Hg(lit.)
density 1.128 g/mL at 25 °C(lit.)
refractive index 1.4330 to 1.4360
FEMA 2374 | DIETHYL MALATE
Fp 185 °F
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Sparingly), Ethyl Acetate (Slightly)
form clear liquid
pka12.35±0.20(Predicted)
color Colorless to Light yellow
Odorat 100.00 %. brown sugar sweet wine fruity herbal
Odor Typecaramellic
JECFA Number620
Dielectric constant10.2(18℃)
LogP0.23
EPA Substance Registry SystemButanedioic acid, hydroxy-, diethyl ester (7554-12-3)
Safety Information
WGK Germany 3
HS Code 2918.19.9000
MSDS Information
ProviderLanguage
SigmaAldrich English
Diethyl malate Usage And Synthesis
Chemical PropertiesDiethyl malate has a fruity odor with a pleasant herbaceous undertone. It is an ester of dicarboxylic acid
OccurrenceIt exhibits two optically active isomers in addition to the optically inactive form; the most common is the l-isomer; reported present in the cultures of certain fungi (Rhizopus). Reported found in raspberry, cognac, malt whiskey, cider, sherry, white, red, port, sparkling, rose, strawberry and bilberry wines
UsesDiethyl DL-Malate is used as a reagent in the synthesis of dicarboxylic nitroxyalkylamides and nitroxyalkylimides as anti-ischemic agents.
PreparationThe l-isomer can be prepared by esterification of the l-isomer of the acid with alcohol in the presence of HCl.
DefinitionChEBI: Diethyl malate is a malate ester obtained by the formal condensation of the two carboxy groups of malic acid with two molecules of ethanol respectively. It has a role as a metabolite.
Synthesis Reference(s)Synthesis, p. 138, 1982 DOI: 10.1055/s-1982-29718
Diethyl malate Preparation Products And Raw materials
Raw materialsL-Malic acid-->YSAVZVORKRDODB-UHFFFAOYSA-N-->Diethyl fumarate-->Water-->Levulinic acid-->Ethanol-->2-Methyltetrahydrofuran-->DL-Malic acid-->Furfural
Tag:Diethyl malate(7554-12-3) Related Product Information
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