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Danazol

Danazol Suppliers list
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: Product Name:17230-88-5
CAS:17230-88-5
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: career henan chemical co
Tel: +86-371-86658258
Email: sales@coreychem.com
Products Intro: Product Name:Danazol
CAS:17230-88-5
Purity:98% Package:1ASSAYS;1USD
Company Name: Chongqing Chemdad Co., Ltd
Tel: +86-13650506873
Email: sales@chemdad.com
Products Intro: Product Name:Danazol
CAS:17230-88-5
Purity:0.98 Package:1kg,2kg,5kg,10kg,25kg
Company Name: Zhuozhou Wenxi import and Export Co., Ltd
Tel: +8613111626072 (WhatsApp)
Email: zzwenxi@126.com
Products Intro: Product Name:Danazol
CAS:17230-88-5
Purity:99%+ HPLC Package:1KG;15USD|100KG;12USD|1000KG;10USD
Company Name: Jinan Honest Pharm Co., Ltd
Tel: +86-15318812076
Email: sale@jnhonestpharm.com; honestpharm@163.com;
Products Intro: Product Name:Danazol
CAS:17230-88-5
Purity:99% Package:25kg;

Danazol manufacturers

  • Danazol
  • $15.00-10.00 / KG
  • 2021-07-13
  • CAS:17230-88-5
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
  • Danazol
  • $15.00-10.00 / KG
  • 2021-07-10
  • CAS:17230-88-5
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
  • Danazol USP/EP/BP
  • $1.10 / g
  • 2021-06-08
  • CAS:17230-88-5
  • Min. Order: 1g
  • Purity: 99.9%
  • Supply Ability: 100 Tons Min
Danazol Basic information
Product Name:Danazol
Synonyms:DANZOL;DANAZOL;4-ANDROSTEN-[2,3-D]ISOXAZOLE-17-ALPHA-ETHYNYL-17-BETA-OL;17alpha-pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol;(17A)-PREGNA-2,4-DIEN-20-YNO[2,3-D]ISOXAZOL-17-OL;17BETA-HYDROXY-2,4,17ALPHA-PREGNADIEN-20-YNO[2,3-D]ISOXAZOLE;17a-Ethynyl-17b- hydroxy-4-androsteno[2,3-d]isoxazole;Bonzol
CAS:17230-88-5
MF:C22H27NO2
MW:337.46
EINECS:241-270-1
Product Categories:DANOCRINE;Intermediates & Fine Chemicals;Steroids;Organics;Pharmaceuticals
Mol File:17230-88-5.mol
Danazol Structure
Danazol Chemical Properties
Melting point 224.4-226.80C
alpha D25 +7.5° (ethanol); D25 +21.9° (chloroform)
Boiling point 473.76°C (rough estimate)
density 1.0909 (rough estimate)
refractive index 1.5614 (estimate)
storage temp. -20°C Freezer
pka13.10±0.60(Predicted)
Water Solubility Partly soluble in water. Soluble in chloroform (25 mg/ml), acetone, acetonitrile, and ethanol. 17beta-Hydroxy-2,4,17a-pregnadien-20-yno[2,3-d]isoxazole and 2,4,17a-Pregnadien-20-yno[2,3-d]isoxazol-17-ol are the synonym of this compound.
EPA Substance Registry SystemDanazol (17230-88-5)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 20/21/22-63-36/37/38
Safety Statements 22-36-37/39-26
WGK Germany 3
RTECS TU4157070
HS Code 29372900
MSDS Information
Danazol Usage And Synthesis
Chemical PropertiesWhite Solid
OriginatorDanol,Winthrop,UK,1974
Usesanterior pituitary suppressant
UsesDanazol is an anterior pituitary supressant. Danazol is an anabolic steroid derivative of ethisterone, with mild androgenic side effects (an impeded androgen). Antigonadotropin.
UsesAnterior pituitary supressant. Anabolic steroid derivative of ethisterone, with mild androgenic side effects (an impeded androgen). Antigonadotropin
IndicationsDanazol, a synthetic androgen, has been used to treat the pruritus of primary biliary cirrhosis, urticaria, and also idiopathic pruritus. It has been used for treatment of pruritus associated with polycythemia vera and systemic lupus erythematosus.
Manufacturing ProcessDanazol was prepared from 4.32 grams of 17α-ethynyl-2-hydroxymethylene4-androsten-17β-ol-3-one, 1.00 gram of hydroxylamine hydrochloride, 1.12 grams of fused sodium acetate and 135 ml of acetic acid. To a 500 ml, 3- necked flask, equipped with a sealed Hershberg-type stirrer, a reflux condenser and a stopper, was added the above androstenone derivative in 300 ml of 95% ethanol. Stirring was commenced and a slurry of fused sodium acetate and hydroxylamine hydrochloride in glacial acetic acid was added.
The mixture was refluxed gently on a steam bath for 1? hours. Fifteen minutes after initiating the reaction, the reaction mixture gave a negative ferric chloride test. Most of the ethanol and acetic acid were removed by distillation in vacuo, 300 ml of water and 300 ml of ether were added to the concentrate, and the mixture was shaken. The layers were separated, the aqueous layer extracted with fresh ether, and the combined ether extracts were washed with water, dried over anhydrous sodium sulfate, filtered and evaporated to dryness in vacuo. The residue was crystallized by trituration with ether, and the crystals were collected by filtration, washed with hexane and dried. The mother liquors were concentrated to dryness and dissolved in a minimum amount of acetone, whereupon a second crop was obtained. The two crops were combined, dissolved in ethyl acetate, decolorized with activated charcoal, and recovered by concentration.
The mixture was refluxed gently on a steam bath for 1? hours. Fifteen minutes after initiating the reaction, the reaction mixture gave a negative ferric chloride test. Most of the ethanol and acetic acid were removed by distillation in vacuo, 300 ml of water and 300 ml of ether were added to the concentrate, and the mixture was shaken. The layers were separated, the aqueous layer extracted with fresh ether, and the combined ether extracts were washed with water, dried over anhydrous sodium sulfate, filtered and evaporated to dryness in vacuo. The residue was crystallized by trituration with ether, and the crystals were collected by filtration, washed with hexane and dried. The mother liquors were concentrated to dryness and dissolved in a minimum amount of acetone, whereupon a second crop was obtained. The two crops were combined, dissolved in ethyl acetate, decolorized with activated charcoal, and recovered by concentration.
Brand nameDanocrine (Sanofi Aventis).
Therapeutic FunctionAnterior pituitary suppressant
General DescriptionDanazol, 17α-pregna-2,4-dien-20-yno-[2,3-d]isoxazol-17-ol, is a weak androgen that, in spite ofthe 17α-ethinyl group, has little estrogenic or progestogenicactivity. Danazol has been called a synthetic steroidwith diverse biological effects. Danazol binds to sexhormone–binding globulin (SHBG) and decreases the hepaticsynthesis of this estradiol and testosterone carrier.Free testosterone thus increases. Danazol inhibits FSH andLH production by the hypothalamus and pituitary. It bindsto PRs, GRs, ARs, and ERs. Although the exact mechanismof action is unclear, danazol alters endometrial tissueso that it becomes inactive and atrophic, which allowsdanazol to be an effective treatment for endometriosis.Danazol is also used to treat hereditary angioedema and fibrocysticbreast disease.
Side effectsDanazol, a synthetic analogue of 17α-ethynyl testosterone, induces amenorrhea, anovulation and endometrial atrophy via suppression of the hypothalamicpituitary-ovary (HPO) axis. This causes an estrogen-deficient state, but it also causes an increase in androgen production. Danazol generally is not well tolerated because of its androgenic and anabolic side effects, including acne, decreased breast size, facial hair, weight gain, and oily skin. This type of therapy is not a viable option for women with liver disease or hyperlipidemia. Because danazol is teratogenic , it is recommended that effective contraception be utilized during treatment.
Veterinary Drugs and TreatmentsBecause of expense and unpredictable efficacy, danazol is not commonly used in veterinary medicine, but has been used as adjunctive therapy (with corticosteroids) in the treatment of canine immunemediated thrombocytopenia and hemolytic anemia, particularly if the patient becomes refractory to glucocorticoids and other immunosuppressive therapy. There is apparently synergism when danazol is combined with corticosteroids for these indications. Once remission is attained, some dogs may have their dosage reduced or other medications may be eliminated and be controlled with danazol alone. In humans, danazol has been used for the treatment of endometriosis, fibrocystic breast disease, idiopathic thrombocytopenic purpura and a variety of other conditions.
Danazol Preparation Products And Raw materials
Raw materialsAcetic acid-->Sodium acetate
Tag:Danazol(17230-88-5) Related Product Information
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