|
|
| Product Name: | OSMI-1 | | Synonyms: | OSMI-1;Benzeneacetamide, α-[[(1,2-dihydro-2-oxo-6-quinolinyl)sulfonyl]amino]-N-(2-furanylmethyl)-2-methoxy-N-(2-thienylmethyl)-, (αR)-;OSMI-1 >=98% (HPLC);(R)-N-(Furan-2-ylmethyl)-2-(2-methoxyphenyl)-2-(2-oxo-1,2-dihydroquinoline-6-sulfonamido)-N-(thiophen-2-ylmethyl)acetamide;cell-permeable,Inhibitor,OGT,Diacylglycerol acyltransferase,O-GlcNAcylation,toxicity,mammalian,inhibit,Acyltransferase,zebrafish,OSMI-1,acyl-CoA:cholesterol acyltransferase,Diglyceride acyltransferase,OSMI 1,OSMI1,O-GlcNAc,mono- acylglycerol acyltransferase,transferase | | CAS: | 1681056-61-0 | | MF: | C28H25N3O6S2 | | MW: | 563.64 | | EINECS: | | | Product Categories: | API | | Mol File: | 1681056-61-0.mol |  |
| | OSMI-1 Chemical Properties |
| density | 1.389±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMF: 25 mg/mL; DMF:PBS (pH 7.2) (1:5): 0.16 mg/mL; DMSO: 20 mg/mL | | pka | 8.77±0.20(Predicted) | | form | powder | | color | white to beige |
| | OSMI-1 Usage And Synthesis |
| Uses | OSMI 1 is a novel inhibitor of O-GlcNAc transferase (OGT). | | Uses | OSMI-1 (OGT with a small molecule inhibitor) has been used in proximal ligation assay, Sox2 (SRY (sex determining region Y)-Box 2 ) dual luciferase reporter assay, Sox2 ELISA (enzyme linked immunosorbent assay) and other in vivo approaches, to study the O-Linked β-N-acetylglucosamine (O-GlcNAc) mediated regulation of self-renewal genes in cancer. It has also been used to study the Hippo pathway regulation mediated by O-GlcNAc transferase. | | Definition | ChEBI: OSMI-1 is a sulfonamide resulting from the formal condensation of the sulfonic acid group of 2-oxo-1,2-dihydroquinoline-6-sulfonic acid with the primary amino group of (2R)-2-amino-N-(2-furylmethyl)-2-(2-methoxyphenyl)-N-(2-thienylmethyl)acetamide. OSMI-1 is a cell permeable inhibitor of O-linked beta-N-acetylglucosamine transferase (O-GlcNAc transferase, OGT). It has a role as an EC 2.* (transferase) inhibitor and an EC 2.4.1.255 (protein O-GlcNAc transferase) inhibitor. It is a sulfonamide, a member of quinolines, a member of furans, a member of thiophenes, an aromatic ether and a tertiary carboxamide. | | Biochem/physiol Actions | OGT catalyses the attachment of N-acetylglucosamine moieties to a number proteins during post-translational modification. Inhibition of OGT activity might hinder the rate of viral replication in infections such as Herpes simplex viral disease. |
| | OSMI-1 Preparation Products And Raw materials |
|