|
| ANTIMYCIN A1 Basic information |
Product Name: | ANTIMYCIN A1 | Synonyms: | dihydrosamidin;-dioxo-1,5-dioxonan-3-yl)salicylamide;isovalericacid,8-esterwith3-formamido-n-(7-hexyl-8-hydroxy-4,9-dimethyl-2,6;ANTIMYCIN A1;3-(3-formamidosalicylamido)-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl isovalerate;3-Methylbutanoic acid 3-[[3-(formylamino)-2-hydroxybenzoyl]amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl ester;3-Methylbutyric acid 3-[[3-(formylamino)-2-hydroxybenzoyl]amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl ester;[3-[(3-formamido-2-hydroxybenzoyl)amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl] 3-methylbutanoate | CAS: | 642-15-9 | MF: | C28H40N2O9 | MW: | 548.63 | EINECS: | 211-380-4 | Product Categories: | | Mol File: | 642-15-9.mol | |
| ANTIMYCIN A1 Chemical Properties |
Melting point | 149.5℃ | alpha | D26 +76° (c = 1 in chloroform) | Boiling point | 620.81°C (rough estimate) | density | 1.2468 (rough estimate) | refractive index | 1.5800 (estimate) | storage temp. | −20°C | solubility | DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble | form | A solid |
Hazard Codes | T | Risk Statements | 23/24/25 | Safety Statements | 36/37/39-45 | RIDADR | 3172 | RTECS | NY1503500 | HazardClass | 6.1(a) | PackingGroup | II |
| ANTIMYCIN A1 Usage And Synthesis |
Description | Antimycin A1 is an active component of the antimycin A antibiotic complex. It inhibits electron transport and is active against the plant pathogenic fungus G. cingulate. Antimycin A1 (3.3-160 μM) induces the synthesis of carotenoids in M. marinum. It also inhibits ATP-citrate lyase (Ki = 29.5 μM). | Chemical Properties | Crystals. Soluble in alcohol, ether, acetone, and chloroform; slightly soluble in benzene, carbon tetrachloride, and petroleum ether; insoluble in water. | Chemical Properties | Antimycin (A3C26H36N2O9) and (Antimycin
A1) C28H40N2O9 are crystalline solids. | Uses | Antimycin A1 is the most hydrophobic of the four analogues of the antimycin A complex. Like all antimycins, antimycin A1 exhibits potent antifungal, anthelmintic, insecticidal, antiviral and antitumor activity across a range of bioassays. Although broadly active as respiration inhibitors, more recent investigation has highlighted the importance of individual members of the complex as bioprobes. Antimycin A1 inhibits angiogenesis via a decrease in VEGF production caused by inhibition of HIF-1a activation. | Uses | Experimentally as fungicide, insecticide, miticide. | Definition | An antibiotic substance said to have strong fungicidal properties. | Potential Exposure | Specific uses for antimycin A were
not found, however, antimycin A1, and antimycin A3 are
reported to be antibiotic substances produced by streptomyces
for use as a fungicide, possible insecticide and miticide.
Registered as a pesticide in the U.S. | Shipping | UN2811 Toxic solids, organic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials, Technical
Name Required. |
| ANTIMYCIN A1 Preparation Products And Raw materials |
|