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3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid HCL

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Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:Acoramidis hydrochloride
CAS:2242751-53-5
Purity:99.57% Package:1mg;58USD|5mg;148USD|10mg;238USD
Company Name: Aladdin Scientific
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Products Intro: Product Name:Acoramidis hydrochloride
CAS:2242751-53-5
Purity:98% Package:$300.9/5mg;$480.9/10mg;$950.9/25mg;$1450.9/50mg;$2250.9/100mg;Bulk package Remarks:98%
Company Name: Shaanxi Dideu New Materials Co. Ltd
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Products Intro: Product Name:Acoramidis hydrochloride
CAS:2242751-53-5
Purity:98% Package:25kg
Company Name: Shanghai Hanhong Scientific Co., Ltd.
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Products Intro: Product Name:3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid HCL
CAS:2242751-53-5
Package:5KG;1KG;100kg;1000kg
Company Name: Chongqing jooe co., ltd
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Products Intro: Product Name:Acoramidis hydrochloride
CAS:2242751-53-5
Purity:0.99 Package:1kg,5kg,25kg

3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid HCL manufacturers
3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid HCL Basic information
Product Name:3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid HCL
Synonyms:3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid HCL;Acoramidis hydrochloride;AG10 hydrochloride;3-(3-(3,5-Dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid hydrochloride;Acoramidis?hydrochloride?(AG10 hydrochloride);Acoramidis hydrochloride, 10 mM in DMSO
CAS:2242751-53-5
MF:C15H18ClFN2O3
MW:328.77
EINECS:
Product Categories:3-(3-(3,5-DIMET
Mol File:2242751-53-5.mol
3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid HCL Structure
3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid HCL Chemical Properties
solubility DMSO: Sparingly soluble: 1-10 mg/ml
form Solid
color White to light yellow
Safety Information
MSDS Information
3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid HCL Usage And Synthesis
UsesAcoramidis (AG10) hydrochloride is an orally active and selective kinetic stabilizer of WT and V122I-TTR (transthyretin). Acoramidis (AG10) hydrochloride is used in the study for transthyretin amyloidosis[1][2].
in vivo
Animal Model:Wistar rats[1].
Dosage:50 mg/kg/d (Toxicity Analysis).
Administration:Oral gavage, daily for 28 d.
Result:Showed the plasma Cmax of ～40 μM and histopathological evaluation of liver, kidney, heart, spleen, thymus, and lung showed no signs of pathologic processes in the AG10-treated animals
References[1] Sravan C Penchala, et al. AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9992-7. DOI:10.1073/pnas.1300761110
[2] Jonathan C Fox, et al. First-in-Human Study of AG10, a Novel, Oral, Specific, Selective, and Potent Transthyretin Stabilizer for the Treatment of Transthyretin Amyloidosis: A Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study in Healthy Adult Volunteers. Clin Pharmacol Drug Dev. 2020 Jan;9(1):115-129. DOI:10.1002/cpdd.700
[3] Stephen P Soltoff, et al. Evidence that tyrphostins AG10 and AG18 are mitochondrial uncouplers that alter phosphorylation-dependent cell signaling. J Biol Chem. 2004 Mar 19;279(12):10910-8. DOI:10.1074/jbc.M305396200
3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid HCL Preparation Products And Raw materials
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