| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:CD40-TRAF6 Signaling Inhibitor, 6877002 - Calbiochem
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| Company Name: |
Riedel-de Haen AG
|
| Tel: |
800 558-9160 |
| Email: |
|
| Products Intro: |
Product Name:CD40-TRAF6 Signaling Inhibitor, 6877002 - Calbiochem
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| | CD40-TRAF6 Signaling Inhibitor, 6877002 - Calbiochem Basic information |
| | CD40-TRAF6 Signaling Inhibitor, 6877002 - Calbiochem Chemical Properties |
| | CD40-TRAF6 Signaling Inhibitor, 6877002 - Calbiochem Usage And Synthesis |
| General Description | A cell-permeable, bioavailable propenone compound that specifically targets TNF receptor-associated factor 6 (TRAF6; Kd = 97 μM for TRAF6 C-domain) and disrupts its functional coupling with CD40. A six-week treatment of C57BL/6 mice fed high fat diet (HFD) with this compound show significant improvement in insulin sensitivity and hepatosteatosis without affecting HFD-induced weight gain. Also reported to reduce gonadal adipose tissue inflammation and diminish the number of CD11b+F4/80+CD11c+ M1 macrophages. Inhibits NF-κB activation in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells (IC50 15.9 μM) and reduce IL-1β and IL-6 expression in anti-CD40 antibody FGK45-stimulated primary bone marrow-derived macrophages. | | Biochem/physiol Actions | Cell permeable: yes |
| | CD40-TRAF6 Signaling Inhibitor, 6877002 - Calbiochem Preparation Products And Raw materials |
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