2'-Deoxyuridine 5'-monophosphate disodium salt manufacturers
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| | 2'-Deoxyuridine 5'-monophosphate disodium salt Basic information |
| Product Name: | 2'-Deoxyuridine 5'-monophosphate disodium salt | | Synonyms: | dump;2''-Deoxyuridine-5''-monophosphoric acid disodium salt;2'-deoxyuridine 5'-monophosphate*disodium sigma G;5'-Uridylic acid, 2'-deoxy-, disodium salt;2'-Deoxyuridine-5'-monophosphate,sodiumsalt;2'-DEOXYURIDINE 5'-MONOPHOSPHATEDISODIUM SIGMA GRA;2''-DEOXYURIDINE 5''-MONOPHOSPHATE DISODIUM SALT (DUMP-NA2);2'-Deoxy-5'-uridylic acid disodium salt | | CAS: | 42155-08-8 | | MF: | C9H14N2NaO8P | | MW: | 332.18 | | EINECS: | 255-687-1 | | Product Categories: | Nucleotide | | Mol File: | 42155-08-8.mol |  |
| | 2'-Deoxyuridine 5'-monophosphate disodium salt Chemical Properties |
| storage temp. | -20°C | | solubility | PBS (pH 7.2): 1 mg/ml | | form | Powder | | color | White to Off-white | | Water Solubility | Soluble in water. | | CAS DataBase Reference | 42155-08-8(CAS DataBase Reference) |
| | 2'-Deoxyuridine 5'-monophosphate disodium salt Usage And Synthesis |
| Description | 2'-Deoxyuridine 5'-monophosphate disodium salt is a nucleoside analog that inhibits the synthesis of DNA and RNA by inhibiting the enzyme thymidylate synthase, which prevents the formation of dTMP from deoxyuridine 5'-triphosphate. 2'-Deoxyuridine 5'-monophosphate disodium salt has been shown to be effective in treating squamous cell cancer and hyperproliferative diseases such as chronic myelogenous leukemia. 2'-Deoxyuridine 5'-monophosphate disodium salt is also used as an antiviral agent against HIV, herpes simplex virus, and varicella zoster virus. | | Uses | 2?-Deoxyuridine 5?-monophosphate (dUMP) is used by the enzyme thymidylate synthetase (TS) (EC 2.1.1.45) for the de novo production of dTMP. dUMP is used as the reference substrate in studies of dUMP analogues in potential chemotherapy applications. | | General Description | 2′-Deoxyuridine 5′-monophosphate disodium salt (dUMP) is a substrate for thymidylate synthase and is converted to deoxythymidine monophosphate (dTMP). | | Biochem/physiol Actions | 2′-Deoxyuridine 5′-monophosphate disodium salt (dUMP) conversion to pyrimidine is inhibited by methotrexate. The inhibition of dUMP to deoxythymidine monophosphate (dTMP) at the methylation step is a key in controlling bacterial and eukaryotic cell growth. |
| | 2'-Deoxyuridine 5'-monophosphate disodium salt Preparation Products And Raw materials |
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