(ISOCYANOIMINO)TRIPHENYLPHOSPHORANE manufacturers
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| | (ISOCYANOIMINO)TRIPHENYLPHOSPHORANE Basic information |
| Product Name: | (ISOCYANOIMINO)TRIPHENYLPHOSPHORANE | | Synonyms: | Nsc371099;(ISOCYANOIMINO)TRIPHENYLPHOSPHORANE;1-methylidyne-2-(triphenyl-lambda~5~-phosphanylidene)diazanium;N-isocyaniminotriphenylphosphorane;(N-Isocyanoimino)triphenylphosphorane 95%;(N-Isocyanoimino)Triphenylphosphorane;(N-Isocyanoi;(Isocyanoimino)triphenylphosphorane> | | CAS: | 73789-56-7 | | MF: | C19H15N2P | | MW: | 302.309561 | | EINECS: | | | Product Categories: | | | Mol File: | 73789-56-7.mol |  |
| | (ISOCYANOIMINO)TRIPHENYLPHOSPHORANE Chemical Properties |
| Melting point | 160-161 °C | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | solid | | color | White to Light yellow to Light orange |
| | (ISOCYANOIMINO)TRIPHENYLPHOSPHORANE Usage And Synthesis |
| Uses | Despite growing interest for therapeutic and other biological applications, cyclic peptidomimetics are challenging to synthesize. As reported by the lab of Andrei Yudin, (N-isocyanoimino)triphenylphosphorane (Pinc
) enables zwitterionic-controlled generation of peptide macrocyles from linear peptides and aldehydes. Containing a 1,3,4-oxadiazole, the resulting peptide exhibits both improved membrane permeability, lipophilicity, and aqueous solubility.
Different functional groups can be introduced by varying the aldehyde, and initial work used propionaldehyde (538124), phenylacetaldehyde (107395), and isovaleraldehyde (146455).
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| | (ISOCYANOIMINO)TRIPHENYLPHOSPHORANE Preparation Products And Raw materials |
| Preparation Products | 2-(4-bromophenyl)-1,3,4-oxadiazole-->3-(m-Tolyl)-1H-pyrazole-->2-Propynenitrile, 3-phenyl- (9CI)-->2-(3-Methylphenyl)-1,3,4-oxadiazole-->1,3,4-Oxadiazole, 2-[1,1'-biphenyl]-4-yl--->2-(3-bromophenyl)-1,3,4-oxadiazole-->2-(3-Fluoro-phenyl)-[1,3,4]oxadiazole |
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