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| | PANDINOTOXIN-K ALPHA Basic information |
| | PANDINOTOXIN-K ALPHA Chemical Properties |
| storage temp. | −20°C | | form | powder | | color | off-white | | Sequence | Thr-Ile-Ser-Cys-Thr-Asn-Pro-Lys-Gln-Cys-Tyr-Pro-His-Cys-Lys-Lys-Glu-Thr-Gly-Tyr-Pro-Asn-Ala-Lys-Cys-Met-Asn-Arg-Lys-Cys-Lys-Cys-Phe-Gly-Arg (Disulfide bridge: Cys4-Cys25,Cys10-Cys30,Cys14-Cys32) |
| | PANDINOTOXIN-K ALPHA Usage And Synthesis |
| Uses | Pandinotoxin Kα, isolated from the venom of Pandinus imperator, is the inhibitor of A-type potassium channel[1]. | | IC 50 | Kv4.3; Kv3.4; Kv1.4 | | References | [1] T C Tenenholz, et al. Solution Structure forPandinusToxin K-α (PiTX-Kα), a Selective Blocker of A-Type Potassium Channels. Biochemistry. 1997 Mar 11;36(10):2763-71. DOI:10.1021/bi9628432
[2] Targeting Kai-Zheng Duan, et al. A-type K(+) channels in primary sensory neurons for bone cancer pain in a rat model. Pain.2012 Mar;153(3):562-574. DOI:10.1016/j.pain.2011.11.020 |
| | PANDINOTOXIN-K ALPHA Preparation Products And Raw materials |
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