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| Product Name: | T62 | | Synonyms: | (2-AMino-4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl)(4-chlorophenyl)Methanone;(2-amino-4,5,6,7-tetrahydro-1-benzothiophen-3-yl)-(4-chlorophenyl)methanone;Adenosine A1 receptor activator T62;(2-Amino-4,5,6,7-tetrahydrobenzo[b]thien-3-yl)(4-chlorophenyl)methanone;allosteric,Inhibitor,Adenosine A1 receptor activator T62,P1 receptor,adenosine,hypersensitivity,Adenosine Receptor,α2-adrenoceptors,antihypersensitivity,intrathecal,Enhancer,neuropathic,Adenosine A-1 receptor activator T62,inhibit;Methanone, (2-amino-4,5,6,7-tetrahydrobenzo[b]thien-3-yl)(4-chlorophenyl)-;3-(4-chlorobenzoyl)-4,5,6,7-tetrahydro-1-benzothiophen-2-amine;Adenosine A1 receptor activator T62, 10 mM in DMSO | | CAS: | 40312-34-3 | | MF: | C15H14ClNOS | | MW: | 291.8 | | EINECS: | | | Product Categories: | | | Mol File: | 40312-34-3.mol |  |
| Melting point | 136-138 °C | | Boiling point | 527.0±50.0 °C(Predicted) | | density | 1.337±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: ~20 mg/mL | | form | crystalline | | pka | -1.28±0.20(Predicted) | | color | orange |
| Uses | T62 is an allosteric enhancer of A1 adenosine receptor. T62 is useful in the treatment of patients with neuropathic pain. | | in vivo | Adenosine A1 receptor activator T62 (0.3-3 μg; intrathecal administration; male SpragueDawley rats) treatment produces a dose-dependent antihypersensitivity effect, with no effect on ambulation or activity level[1]. | Animal Model: | Male SpragueDawley rats (250 g) after paw incision surgery[1] | | Dosage: | 0.3 μg, 0.5 μg, 1 μg, and 3 μg | | Administration: | Intrathecal administration | | Result: | Produced a dose-dependent antihypersensitivity effect, with no effect on ambulation or activity level. The ED40 (95% confidence interval) was 0.77 (0.63-0.91) μg.
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| | T62 Preparation Products And Raw materials |
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