|
|
| | KDM2A/7A-IN-1 Basic information |
| Product Name: | KDM2A/7A-IN-1 | | Synonyms: | KDM2A/7A-IN-1;KDM-IN-6;1H-Indole-3-carbonitrile, 1-acetyl-2,3-dihydro-3-phenyl-2-[5-[7-(1-pyrrolidinyl)heptyl]-3-pyridinyl]-, (2S,3S)-;KDM2A/7AIN1,KDM2A/7A IN 1,KDM-2A/7A-IN-1 | | CAS: | 2169272-46-0 | | MF: | C33H38N4O | | MW: | 506.68 | | EINECS: | | | Product Categories: | | | Mol File: | 2169272-46-0.mol |  |
| | KDM2A/7A-IN-1 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO |
| | KDM2A/7A-IN-1 Usage And Synthesis |
| Biological Activity | KDM2A/7A-IN-1 is a first-in-class, selective and cell-passing inhibitor of histone lysine demethylase KDM2A/7A with IC50 value of 0.16 μM for KDM2A It is 75 times more potent than other JmjC lysine demethylases, and has no effect on methyltransferases and histone acetyltransferases. | | in vitro | KDM2A/7A-IN-1 ((S,S)-6) is a first-in-class, selective and cell-permeable inhibitor of histone lysine demethylases KDM2A/7A, with an IC 50 of 0.16 μM for KDM2A, exhibits 75 fold selevtivity over other JmjC lysine demethylases, and is inactive to methyl transferases, and histone acetyl transferases.
KDM2A/7A-IN-1 (0.4, 3.1, 6.2 μM) augments cellular H3K36me2 levels in HeLa cells ectopically expressing catalytically active KDM2A. | | target | |
| | KDM2A/7A-IN-1 Preparation Products And Raw materials |
|