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Product Name:GABAB receptor antagonist 1
CAS:797-17-1
Purity:98% Package:5mg；10mg；20mg；50mg；100mg；200mg
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GABAB receptor antagonist 1 manufacturers
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| | GABAB receptor antagonist 1 Basic information |
| | GABAB receptor antagonist 1 Chemical Properties |
| Melting point | 136-139 °C (decomp) | | Boiling point | 404.3±37.0 °C(Predicted) | | density | 1.125±0.06 g/cm3(Predicted) | | pka | 2.26±0.54(Predicted) |
| | GABAB receptor antagonist 1 Usage And Synthesis |
| Uses | (E/Z)-CLH304a (GABAB receptor antagonist 1) is a mixture of (E)-CLH304a and (Z)-CLH304a. (E)-CLH304a (CLH304a; HY-129636) is a specific and noncompetitive GABAB receptor negative allosteric modulator (NAM). CLH304a inhibits Baclofen (HY-B0007)-induced ERK1/2 phosphorylation in HEK293 cells overexpressing GABAB receptors[1][2]. | | References | [1] Chen LH, et al. Discovery of a Negative Allosteric Modulator of GABAB Receptors. ACS Med Chem Lett. 2014 May 27;5(7):742-7. DOI:10.1021/ml500162z
[2] Bing Sun, et al. A negative allosteric modulator modulates GABAB-receptor signalling through GB2 subunits. Biochem J. 2016 Mar 15;473(6):779-87. DOI:10.1042/BJ20150979 |
| | GABAB receptor antagonist 1 Preparation Products And Raw materials |
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