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Phenylacetic acid

Phenylacetic acid Basic information
Description References
Product Name:Phenylacetic acid
Synonyms:Phenylacetic acid,α-Tolylic acid, Benzeneacetic acid, PAA;Phenylacetic acid, 98.5%;Phenylacetic acid (PAA);TropicaMide Related CoMpound D;Fenylazijnzuur;Acetic acid, phenyl-;aceticacid,phenyl-;acidephenylacetique
Product Categories:Building Blocks;C8;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Citrus aurantium (Seville orange);Nutrition Research;Organic Building Blocks;Phytochemicals by Plant (Food/Spice/Herb);API
Mol File:103-82-2.mol
Phenylacetic acid Structure
Phenylacetic acid Chemical Properties
Melting point 76-78 °C(lit.)
Boiling point 265 °C(lit.)
density 1.081 g/mL at 25 °C(lit.)
vapor density ~4 (vs air)
vapor pressure 1 mm Hg ( 97 °C)
refractive index 1.5120 (estimate)
Fp 132°C
storage temp. Store at RT.
pka4.28(at 18℃)
Water Solubility 15 g/L (20 ºC)
Merck 14,7268
BRN 1099647
Stability:Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference103-82-2(CAS DataBase Reference)
NIST Chemistry ReferenceBenzeneacetic acid(103-82-2)
EPA Substance Registry SystemBenzeneacetic acid(103-82-2)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36-37/39
WGK Germany 1
RTECS AJ2430000
HS Code 29163400
Hazardous Substances Data103-82-2(Hazardous Substances Data)
MSDS Information
Benzeneacetic acid English
SigmaAldrich English
ALFA English
Phenylacetic acid Usage And Synthesis
DescriptionNaturally occurring in various types of fruits and other plants, phenylacetic acid is a fragrant phenolic used as a perfume agent and food additive.  Its pharmaceutical uses include the treatment of hyperammonemia for patients with deficiencies related to the urea cycle, and as a side chain precursor in the production of penicillin G. It also plays a role in the production of Camylofin, Bendazol, and Triafungin.
Because of its use in the production of phenylacetone (used to manufacture substituted amphetamines, including methamphetamine), it is a controlled substance.
Chemical Propertieswhite crystals with a honey-like odour
UsesPhenylacetic Acid is used in the synthesis of Diclofenac (D436450) and its metabolite 4'-Hydroxydiclofenac (H825225), which is the principal human metabolite of Diclofenac.
DefinitionChEBI: A monocarboxylic acid that is toluene in which one of the hydrogens of the methyl group has been replaced by a carboxy group.
Purification MethodsCrystallise the acid from pet ether (b 40-60o), isopropyl alcohol, 50% aqueous EtOH or hot water (m 77.8-78.2o). Dry it in vacuo. It can be distilled under a vacuum. [Beilstein 9 II 294, 9 III 2169.]
Tag:Phenylacetic acid(103-82-2) Related Product Information
Acetophenone Benzeneacetonitrile ACETIC ACID Ascoric Acid 4-Methoxyphenylacetic acid 2-Chlorophenylacetic acid 9-HYDROXYFLUORENE-9-CARBOXYLIC ACID Benzocyclobutyl-1-carboxylic acid 1-Phenyl-1-cyclopropanecarboxylic acid 1-(4-CHLOROPHENYL)-1-CYCLOPROPANECARBOXYLIC ACID 1-Phenylcyclopentanecarboxylic acid 1-(4-CHLOROPHENYL)-1-CYCLOPENTANECARBOXYLIC ACID 1-(4-CHLOROPHENYL)-1-CYCLOBUTANECARBOXYLIC ACID 9-Carboxyfluorene 4-Hydroxyphenylacetic acid 4-Biphenylacetic acid DL-Thioctic acid 4-Chlorophenylacetic acid