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n-Butyllithium

n-Butyllithium Suppliers list
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Email: info@dakenchem.com
Products Intro: Product Name:n-Butyllithium
CAS:109-72-8
Purity:99% Package:100g,500g,1kg,5kg,10kg
Company Name: Beijing Cooperate Pharmaceutical Co.,Ltd.
Tel: +86-10-60279497 +86(0)15646567669
Email: sales01@cooperate-pharm.com
Products Intro: Product Name:n-Butyllithium
CAS:109-72-8
Purity:98% Package:100G;1KG;5KG;10KG;25KG;50KG;100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: CAS:109-72-8
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Mainchem Co., Ltd.
Tel: +86-0592-6210733
Email: sales@mainchem.com
Products Intro: Product Name:n-Butyllithium
CAS:109-72-8
Company Name: Hangzhou FandaChem Co.,Ltd.
Tel: 0086 158 5814 5714 (Mobile; WhatsApp; Telegram)
Email: fandachem@gmail.com
Products Intro: Product Name:n-Butyllithium 1.6M-2.5M in Hexane
CAS:109-72-8
Purity:1.6M-2.5M?in?Hexane Package:steel?drum

Lastest Price from n-Butyllithium manufacturers

  • n-Butyllithium
  • US $7.00 / KG
  • 2018-08-17
  • CAS:109-72-8
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 1000KG
  • n-Butyllithium
  • US $2.00 / KG
  • 2018-08-07
  • CAS: 109-72-8
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 20KG
n-Butyllithium Basic information
Chemical Properties Usage Identifying Procedures Warnings and precautions Category Explosivity characteristics Flammability characertistics Storage Extinguisher
Product Name:n-Butyllithium
Synonyms:BUTYLLITHIUM, 2.0M SOLUTION IN PENTANE;BUTYLLITHIUM, 1.6M SOLUTION IN HEXANES;BUTYLLITHIUM SOLUTION, ~1.6 M IN HEXANE;BUTYLLITHIUM, 2.0M SOLUTION IN CYCLOHEXA NE;BUTYLLITHIUM SOLUTION, ~10 M IN HEXANE;BUTYLLITHIUM, 10.0M SOLUTION IN HEXANES;N-butyl lithium Solution;n-utyllithium
CAS:109-72-8
MF:C4H9Li
MW:64.06
EINECS:203-698-7
Product Categories:Metal Compounds;Organometallics;Alkyl Metals;Classes of Metal Compounds;Grignard Reagents & Alkyl Metals;Li (Lithium) Compounds;Synthetic Organic Chemistry;Typical Metal Compounds;metal alkyl;Alkyl;Chemical Synthesis;Organic Bases;Organolithium;Organometallic Reagents;Synthetic Reagents
Mol File:109-72-8.mol
n-Butyllithium Structure
n-Butyllithium Chemical Properties
Melting point -95 °C
Boiling point 80 °C
density 0.68 g/mL at 20 °C
Fp 10 °F
storage temp. 2-8°C
solubility Miscible with diethyl ether and cyclohexane.
form liquid
color yellow
OdorOdor of the solvent
Water Solubility vigorous reaction
Sensitive Air & Moisture Sensitive
BRN 1209227
CAS DataBase Reference109-72-8(CAS DataBase Reference)
NIST Chemistry ReferenceButyl lithium(109-72-8)
EPA Substance Registry SystemLithium, butyl-(109-72-8)
Safety Information
Hazard Codes F,C,N
Risk Statements 14/15-17-34-48/20-51/53-62-65-67-63-35-11-15-50/53-66
Safety Statements 6-9-16-26-36/37/39-45-61-62-6A-46-43B-43-60-33-29-5
RIDADR UN 3399 4.3/PG 1
WGK Germany 3
3-10
TSCA Yes
HazardClass 4.3
PackingGroup I
ToxicityThere is little toxicity data available for the butyllithiums; for data on ether and hydrocarbon solvents, see the appropriate LCSSs.
MSDS Information
ProviderLanguage
n-Butyllithium English
SigmaAldrich English
ACROS English
ALFA English
n-Butyllithium Usage And Synthesis
Chemical PropertiesColorless or slightly yellow transparent liquid at room temperature, also comes in powder form. Boiling point is 80-90℃(0.013Pa), relative density is 0.68-0.70. Soluble in many organic solvents. Stable in room temperature, lithium hydride removable by heating. Disintegrates in water, soluble in hydrocarbons and ethers, forms complex compounds with ethers, amines, and sulfides, and uses N-hexane as a solvent.
UsageN-Butyllithium solution is mostly used as a pharmaceutical intermediate to synthesize anionic polymerization initiator. It is also used to produce rubber (such as integral rubber SIBR, which is the most versatile diene rubber to date), fragrance, liquid crystal materials, and other industries. It is a chemical product intermediate, linking agent, alkylating agent, and polymerization catalyst. As a catalyst, N-Butyllithium is widely used as a pharmaceutical intermediate, liquid crystal monomer, and pesticide production catalyst. It is also widely used in organic syntheses, especially in growing carbon chains, and it is a staple laboratory product in reactions such as: 1) Metallization reaction: R-H + n-Butyl-Li → R-Li + Butane, in which the produced lithium alkyl can react with many substances. 2) Direct metallization: the aromatic compound that connects the substitute reacts with N-Butyllithium, and lithium metal can be attached to the aromatic compound. 3) Nucleophilic addition and substitution reaction. 4) Halogen-metal replacement.
Identifying ProceduresN-Butyllithium must be calibrated through single titration as follows:
1) Titration solution: 1mol/L SEC butanol/dimethylbenzene solution (butanol and dimethylbenzene must be dried with an activated 5A molecular sieve)
2) Indicator: 2,2’-dipyridine
3) Solvent: dimethylbenzene (must be dried with an activated 5A molecular sieve).
4) Operation method: Under the protection of argon, add magneton, 20ml dimethylbenzene and a small amount of indicator into a 100ml 3-lipped bottle with a tipping plug. Then use a precisely marked 2ml injector to swiftly transfer 2ml N-Butyllithium into the bottle (the air in the injector must be replaced with argon, which must then be expelled when collecting the N-Butyllithium; fill and drain the injector in the N-Butyllithium multiple times to prevent any water or air from remaining in the injector). The system should turn a purplish red. Then, wash, dry, and rinse the same injector with titration solution 2-3 times (to prevent any change in the amount added) and titrate the solution until the system turns yellow, and cease titration.
5) Repeat titration once; if the percent error between the two times is within 2%, the result can be regarded as correct.
6) Titration result: titration solution (ml)/2 to obtain N-Butyllithium concentration.
Warnings and precautions1) N-Butyllithium is extremely combustible when in contact with air; when measuring, the needle of the injector will eject sparks.
2) The entire process must be protected by argon for safety precaution.
3) If N-Butyllithium catches fire, it must be extinguished with sand, which must be placed within arm’s reach at all times.
When preparing and using N-Butyllithium, do not operate alone in case of emergency
CategorySpontaneously combustible when in contact with water
Explosivity characteristicsMay explode in combination with phenylethylene
Flammability characertisticsCombusts in air at a concentration abover 20%; combusts upon contact with water and carbon dioxide; flammable when in contact with heat and open flame.
StorageStore in ventilated, cool and dry spaces; must be waterproof and carbon dioxide-proof.
ExtinguisherDry powder
Chemical Propertiesclear yellow solution
storageIn particular, butyllithium should be stored and handled in areas free of ignition sources, and containers of butyllithium should be stored under an inert atmosphere. Work with butyllithium should be conducted in a fume hood under an inert gas such as nitrogen or argon. Safety glasses, impermeable gloves, and a fire-retardant laboratory coat are required.
IncompatibilitiesThe butyllithiums are extremely reactive organometallic compounds. Violent explosions occur on contact with water with ignition of the solvent and of the butane produced. t-Butyllithium will ignite spontaneously in air. The butyllithiums ignite on contact with water, carbon dioxide, and halogenated hydrocarbons. The butyllithiums are incompatible with acids, halogenated hydrocarbons, alcohols, and many other classes of organic compounds.
Flammability and ExplosibilityThe risk of fire or explosion on exposure of butyllithium solutions to the atmosphere depends on the identity of the organolithium compound, the nature of the solvent, the concentration of the solution, and the humidity. t-Butyllithium solutions are the most pyrophoric and may ignite spontaneously on exposure to air. Dilute solutions (1.6 M, 15% or less) of n-butyllithium in hydrocarbon solvents, although highly flammable, have a low degree of pyrophoricity and do not spontaneously ignite. Under normal laboratory conditions (25 °C, relative humidity of 70% or less), solutions of -20% concentration will usually not ignite spontaneously on exposure to air. More concentrated solutions of n-butyllithium (50 to 80%) are most dangerous and will immediately ignite on exposure to air. Contact with water or moist materials can lead to fires and explosions, and the butyllithiums also react violently with oxygen.
Waste DisposalExcess butyllithium solution can be destroyed by dilution with hydrocarbon solvent to a concentration of approximately 5 wt %, followed by gradual addition to water with vigorous stirring under an inert atmosphere. Alternatively, the butyllithium solution can be slowly poured (transfer by cannula for s- or tbutyllithium) into a plastic tub or other container of powdered dry ice.
The residues from the above procedures and excess butyllithium should be placed in an appropriate container, clearly labeled, and handled according to your institution's waste disposal guidelines.
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