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Chlorhexidine digluconate

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Company Name: Shaanxi Dideu Medichem Co. Ltd
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Email: 1015@dideu.com
Products Intro: Product Name:Chlorhexidine digluconate
CAS:18472-51-0
Purity:99.0%+
Company Name: Shanghai Bojing Chemical Co.,Ltd.
Tel: +86-21-37122233
Email: Candy@bj-chem.com
Products Intro: Product Name:Chlorhexidine digluconate
CAS:18472-51-0
Purity:20% Package:25kg/ Drum
Company Name: Panjin Jiahe Shengshi Medical Technology Co., Ltd.
Tel: 0427-6572122
Email: jiahe@jhssw.com
Products Intro: Product Name:Chlorhexidine Gluconate
CAS:18472-51-0
Purity:20% Package:10kg 25kg 200 kilograms per barrel Remarks:Antiseptic and anticorrosion
Company Name: Henan Xiangtong Chemical Co., Ltd.
Tel: 86-371-61312303
Email: cathy@hnxtchem.com
Products Intro: Product Name:Chlorhexidine digluconate
CAS:18472-51-0
Purity:20% Package:1KG;1USD
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.
Tel: 86-0551-65418684 18949823763
Email: info@tnjchem.com
Products Intro: Product Name:Chlorhexidine digluconate
CAS:18472-51-0
Purity:99.9% Package:1KG;5USD

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  • What is Chlorhexidine digluconate?
  • Chlorhexidine digluconate, is a skin antiseptic in use in the health care setting with many potential applications for infecti....
  • Mar 5,2021
Chlorhexidine digluconate Basic information
Product Name:Chlorhexidine digluconate
Synonyms:ChlorhexidineDigluconate,20%Solution;ChlorhexidineGluconate20%SolutionChlorhexidineGluconate20%SolutionBp/Usp/Ep;ChlorhedineGluconate;CHLOROHEXIDINE DIGLUCONATE;CHLOROHEXIDINE GLUCONATE;CHLOROHEXIDINE DIGLUCONATE, SOLUTION;Chlorhexdine digluconate;Chlorhexidin bigluconate
CAS:18472-51-0
MF:C28H42Cl2N10O7
MW:701.61
EINECS:242-354-0
Product Categories:Disinfectant;Broad-spectrum antimicrobial, bactericidal effect;API;VX:15689727968
Mol File:18472-51-0.mol
Chlorhexidine digluconate Structure
Chlorhexidine digluconate Chemical Properties
density 1.06 g/mL at 25 °C(lit.)
storage temp. 2-8°C
solubility water: soluble50% (w/v)
form Liquid
color Colorless
Sensitive Light Sensitive
λmax257nm(H2O)(lit.)
Merck 14,2091
InChIKeyYZIYKJHYYHPJIB-UUPCJSQJSA-N
CAS DataBase Reference18472-51-0(CAS DataBase Reference)
EPA Substance Registry SystemChlorhexidine gluconate (18472-51-0)
Safety Information
Hazard Codes N
Risk Statements 50/53
Safety Statements 61
RIDADR UN 3082 9 / PGIII
WGK Germany -
RTECS DU1950000
TSCA Yes
HazardClass 9
PackingGroup III
HS Code 29252900
ToxicityLD50 in mice (mg/kg): 22 i.v.; 1800 orally (Foulkes)
MSDS Information
ProviderLanguage
SigmaAldrich English
ALFA English
Chlorhexidine digluconate Usage And Synthesis
DescriptionChlorhexidine digluconate solution is a bis(biguanide) family cationic broad spectrum antibiotic that is available in a range of concentrations and has been safely used for over 40 years for a variety of health-related applications; but its specific use for umbilical cord care was uniquely tested in three clinical trials in Nepal, Bangladesh, and Pakistan, in the form of 7.1% chlorhexidine digluconate (CHX). Given the promising results of the trials, in 2013 the World Health Organization (WHO) added CHX to its Model List of Essential Medicines for Children; and in 2014 the WHO issued a new guideline on umbilical cord care, which included a formal recommendation on the use of chlorhexidine.
Chlorhexidine digluconate is a broad spectrum antiseptic. Its mechanism of action involves destabilization of the outer bacterial membrane. It is effective on both Gram-positive and Gram-negative bacteria, although it is less effective with some Gram-negative bacteria.It has both bactericidal and bacteriostatic mechanisms of action, the mechanism of action being membrane disruption, not ATPase inactivation as previously thought.It is also useful against fungi and enveloped viruses, though this has not been extensively investigated. Chlorhexidine is harmful in high concentrations, but is used safely in low concentrations in many products, such as mouthwash and contact lens solutions.
Chemical PropertiesAlmost colourless or pale-yellowish liquid.
OriginatorAbacil,Polfa-Lodz SA,Poland
UsesChlorhexidine is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs.
The gluconate salt form of chlorhexidine, a biguanide compound used as an antiseptic agent with topical antibacterial activity. Chlorhexidine gluconate is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine gluconate penetrates into the cell and causes leakage of intracellular components leading to cell death. Since gram positive bacteria are more negatively charged, they are more sensitive to this agent.
Chlorhexidine digluconate 20% solution is a broad spectrum bacteriostatis antiseptic agent, oral care agent, disinfectant, cosmetic biocide, and preservative. It is very effective against plaque, oral flora including Candida and is active against gram-positive and gram-negative organisms, facultative anaerobes, aerobes, and yeast. It can be used in antiseptic soap, mouthwash that fights plaque, disinfecting wounds and burns, vaginal flushing, hair dyes and bleaches, makeup, and other skin and hair care products.
Useschlorhexidine digluconate is a preservative generally used in concentrations of 0.01 to 0.1 percent to protect against bacteria. It is unstable at high temperatures. Chlorhexidine digluconate is more widely used in europe than in the united States.
UsesHydrogenolysis of benzyl-nitrogen bonds. Chlorhexidine gluconate is an antimicrobial irrigant that is used as an antiseptic for the skin in the healthcare industry. It is used in hospitals to prevent infection of patients during surgeries and can also be found in mouthrinses.
Manufacturing Process35 parts of hexamethylene bis-dicyandiamide, 35 parts of p-chloroaniline hydrochloride and 250 parts of β-etoxyethanol are stirred together at 130- 140°C for 2 hours under reflux. The mixture is then cooled and filtered. The solid is washed with water and crystallised from 50% aqueous acetic acid. 1,1'-Hexamethylene bis(5-(p-chlorophenyl)biguanide) is obtained as colorless plates, melting point 258-260°C. By addition of D-gluconic acid to aqueous solution of chlorhexidine base is prepared 1,1'-hexamethylenebis(5-(pchlorophenyl)biguanide)digluconate (1:2).
Brand nameDyna-Hex (Xttrium); Hibiclens (Regent); Peridex (Zila); Periochip (Dexcel); Periogard (Colgate); Prevacare (Johnson & Johnson).
Therapeutic FunctionAntiseptic
Clinical Use1,6-Di(4 -chlorophenyldiguanido)hexane gluconate (Hibiclens)is the most effective of a series of antibacterial biguanides originallydeveloped in Great Britain.
The antimicrobial properties of the biguanides were discoveredas a result of earlier testing of these compounds aspossible antimalarial agents. Although thebiguanides are technically not bisquaternary ammoniumcompounds and, therefore, should probably be classifiedseparately, they share many physical, chemical, and antimicrobialproperties with the cationic surfactants. Thebiguanides are strongly basic, and they exist as dications atphysiological pH. In chlorhexidine, the positive charges arecounterbalanced by gluconate anions (not shown). Likecationic surfactants, these undergo inactivation when mixedwith anionic detergents and complex anions such as phosphate,carbonate, and silicate.
Chlorhexidine has broad-spectrum antibacterial activitybut is not active against acid-fast bacteria, spores, orviruses. It has been used for such topical uses as preoperativeskin disinfection, wound irrigation, mouthwashes, andgeneral sanitization. Chlorhexidine is not absorbedthrough skin or mucous membranes and does not causesystemic toxicity.
Chlorhexidine digluconate Preparation Products And Raw materials
Raw materials4-Chlorobenzenamine hydrochloride
Tag:Chlorhexidine digluconate(18472-51-0) Related Product Information
Copper(II) gluconate Ferrous gluconate Glucose oxidase Zinc gluconate EC 1.1.1.47 Magnesium gluconate Manganese gluconate D(+)-Glucose D-(+)-Glucono-1,5-lactone Potassium gluconate CALCIUM GLUCONATE MONOHYDRATE Sodium gluconate D(+)-GLUCOSE MONOHYDRATE Biguanide Chlorhexidine Digluconate 20% Chlorophenyl 1-(4-CHLOROPHENYL)BIGUANIDE HYDROCHLORIDE Poly(hexamethylenebiguanide)