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Dicyclohexylcarbodiimide Basic information
Product Name:Dicyclohexylcarbodiimide
Synonyms:N,N'-Dicyclohexylcarbodiimide [for Peptide Synthesis];N,N'-Dicyclohexylcarbodiimide, 0.1M DCM, peptide synthesis grade;N,N'-Dicyclohexylcarbodiimide, 1 M solution in dichloromethane;N,N'-Dicyclohexylcarbodiimide, 1M sol. In N-methylpyrrolidone,peptide synth.grade;N,N'-Dicyclohexylcarbodiimide,>98%;dcc solution;n,n'-dicyclohexylcarbodiimide solution;DCC Dicyclohexylcarbodiimide
Product Categories:Starting Raw Materials & Intermediates;Pharmaceutical Intermediates;Amino Acid Derivatives;Biochemistry;Condensation & Active Esterification;Coupling Reactions (Peptide Synthesis);Miscellaneous;Organics;Coupling Reagent;Nucleosides, Nucleotides & Related Reagents;Peptide Synthesis;Protecting Agents, Phosphorylating Agents & Condensing Agents;Reagents for Oligosaccharide Synthesis;Synthetic Organic Chemistry;Peptide Coupling Reagents;Condensing Agents (DNA / RNA Synthesis);Peptide;Protected Amino Acids;CarbodiimidesSynthetic Reagents;Carbodiimides;Coupling;Peptide Synthesis;Synthetic Reagents;peptides;Zero-Length Crosslinker
Mol File:538-75-0.mol
Dicyclohexylcarbodiimide Structure
Dicyclohexylcarbodiimide Chemical Properties
Melting point 34-35 °C(lit.)
Boiling point 122-124 °C6 mm Hg(lit.)
density 1.247 g/mL at 25 °C
refractive index n20/D 1.48
Fp 190 °F
storage temp. Store below +30°C.
solubility methylene chloride: 0.1 g/mL, clear, colorless
form Waxy Solid or Crystalline Mass
Specific Gravity1.247
color White to pale yellow
Water Solubility Reaction
Sensitive Moisture Sensitive
Merck 14,3096
BRN 610662
Stability:Stable, but moisture sensitive. Combustible. Incompatible with strong oxidizing agents. Avoid exposure to air or moisture.
CAS DataBase Reference538-75-0(CAS DataBase Reference)
NIST Chemistry ReferenceMethanediimine, n,n'-dicyclohexyl-(538-75-0)
EPA Substance Registry SystemDicyclohexylcarbodiimide (538-75-0)
Safety Information
Hazard Codes T,Xn,T+
Risk Statements 23/24/25-34-40-43-41-36/38-21-24-22-62-37/38-10-61-26-38-20/22
Safety Statements 26-36/37/39-45-41-24-37/39-24/25-36-16-53-28
RIDADR UN 2922 8/PG 2
WGK Germany 3
RTECS FF2160000
HazardClass 6.1
PackingGroup II
HS Code 29252000
Hazardous Substances Data538-75-0(Hazardous Substances Data)
ToxicityLD50 orally in Rabbit: 1110 mg/kg LD50 dermal Rat 71 mg/kg
MSDS Information
ACROS English
SigmaAldrich English
ALFA English
Dicyclohexylcarbodiimide Usage And Synthesis
DescriptionDicydohexyl carbodiimide is used in peptide chemistry as a coupling reagent. It is both an irritant and a sensitizer, and caused contact dermatitis in pharmacists and chemists.
Chemical PropertiesColorless solid
Chemical PropertiesN,N0 -Dicyclohexylcarbodiimide (DCC) is a white crystalline solid. Odor is sweet and heavy.
UsesIn the synthesis of peptides.
UsesThis product is mainly used in amikacin, glutathione dehydrants, as well as in synthesis of acid anhydride, aldehyde, ketone, isocyanate; when it is used as dehydrating condensing agent, it reacts to dicyclohexylurea through short-time reaction under normal temperature. This product can also be used in synthesis of peptide and nucleic acid. It is easy to use this product to react with compound of free carboxy and amino-group into peptide. This product is widely used in medical, health, make-up and biological products, and other synthetic fields.
UsesN,N'-Dicyclohexylcarbodiimide is a carbodiimide used to couple amino acids during peptide synthesis. N,N'-Dicyclohexylcarbodiimide is used as a dehydrating agent for the preparation of amides, ketones , nitriles as well as in the inversion and esterification of secondary alcohols.
Usesdicyclohexylcarbodiimide is used as a dehydrating agent at room temperature after a short reaction time, after the reaction product is dicyclohexylurea. the product is very small solubility in an organic solvent, so that easy separation of the reaction product.
DefinitionChEBI: A carbodiimide compound having a cyclohexyl substituent on both nitrogen atoms.
PreparationA stirred mixture of N,N′-dicyclohexylurea (19.7 g), phosphorus pentoxide (100 g), sand (175 g), and pyridine (700 mL) was refluxed for 2.25 h. Stirring was no longer possible after about 30 min. The mixture was filtered and the residue was extracted with pyridine (100 mL). Pyridine was removed from the combined solutions on a flash evaporator, and the residual oil was extracted with boiling petroleum ether (bp 60–80 C°) (2 × 100 mL), and then with diethyl ether (100 mL). The combined extracts were washed with iced water (3×80 mL), dried over calcium chloride, and filtered. The solvents were removed from the filtrate under reduced pressure to give 17.4 g of an oil, which on distillation yielded 13.7 g (76%) of a clear liquid; bp 143 C° (3.5 mmHg), which solidified in the receiver; mp 34–35 C°.
Another method for producing DCC from dicyclohexylurea is a two-step process using phosphoryl chloride in dichloromethane at 40 C° for 4 h under non-basic conditions followed by removal of acidic components with aq. sodium hydroxide. This method, which gives an 89% yield of DCC, has been presented in a patent application.
PreparationPalladium acetate (22 mg, 0.1 mmol), iodine (50 mg, 0.2 mmol), and anhydrous sodium carbonate (320 mg, 3.0 mmol) were placed in a pressure vessel. Cyclohexylamine (0.11 mL, 1.0 mmol) and cyclohexyl isocyanide (0.1 mL, 0.8 mmol) were dissolved in acetonitrile (10 mL) and this solution was added to the reaction vessel, which was then pressurized with oxygen (40 psi) and heated to 100 C° for 3 h. The initially deep-red reaction mixture turned yellow-orange; no Pd black precipitation was observed. There was no obvious reaction rate dependence on oxygen pressure. The mixture was cooled to ambient temperature, depressurized, filtered, and analyzed by GC. DCC was isolated by evaporating the solvent and residual amine, followed by vacuum distillation.
Palladium(II) complexes with a carbodiimide ligand, in which a nitrogen of the linear NbCbN moiety is bonded to the metal center, and bis(carbodiimido)palladium(II) complexes, both derived from isocyanides, have been described.
General DescriptionWhite crystalline solid with a heavy sweet odor.
Air & Water ReactionsSensitive to moisture.
Reactivity ProfileDicyclohexylcarbodiimide is an imide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). Dicyclohexylcarbodiimide is incompatible with acids and oxidizing agents. Dicyclohexylcarbodiimide reacts with water.
HazardA poison by skin contact. Moderately toxic by ingestion and inhalation.
Fire HazardDicyclohexylcarbodiimide is probably combustible.
Contact allergensUsed in peptide chemistry as a coupling reagent. It is both an irritant and a sensitizer and has caused contact dermatitis in pharmacists and chemists.
Potential ExposureLaboratory reagent
ShippingUN2928 Toxic solids, corrosive, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, 8- Corrosive material, Technical Name Required. UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1- Poisonous materials, Technical Name Required
Purification MethodsIt is sampled as a liquid after melting in warm H2O. It is sensitive to air, and it is a potent skin irritant. It can be distilled in a vacuum and is best stored in a tightly stoppered flask in a freezer. It is very soluble in CH2Cl2 and pyridine where the reaction product with H2O, after condensation, is dicyclohexyl urea which is insoluble and can be filtered off. Alternatively dissolve it in CH2Cl2, add powdered anhydrous MgSO4, shake for 4hours, filter, evaporate and distil at 0.6mm pressure and oil bath temperature of 145o. [Bodansky et al. Biochemical Preparations 10, 122 1963, Schmidt & Seefelder Justus Liebigs Ann Chem 571 83 1951, Schmidt et al. Justus Liebigs Ann Chem 612 11 1958, Beilstein 12 IV 72.]
IncompatibilitiesDust may for explosive mixture with air. Reacts with steam and water. N,N0 - Dicyclohexylcarbodiimide is an amine/imide: contact with strong oxidizers may cause fire and explosions. Incompatible with acids, strong bases, strong reducing agents (may form flammable gasses); azo and diazo compounds (may form toxic gases); chlorinated hydrocarbons; nitro compounds. Contact with mixture of acetic acid 1 dinitrogen trioxide may cause explosion. The combustion of amide compounds generate nitrogen oxides (NOx). In the presence of moisture, may attack metals and plastics.
Waste DisposalWhatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste facility. Although not a listed RCRA hazardous waste, this material may exhibit one or more characteristics of a hazardous waste and require appropriate analysis to determine specific disposal requirements. Processing, use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state and local requirements
Tag:Dicyclohexylcarbodiimide(538-75-0) Related Product Information
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