|
|
| Product Name: | RO-31-8220 | | Synonyms: | RO-31-8220;BISINDOLYLMALEIMIDE IX, METHANESULFONATE;3-[1-[3-(AMIDINOTHIO)PROPYL-1H-INDOL-3-YL]-3-(1-METHYL-1H-INDOL-3-YL)MALEIMIDE;BISINDOLYLMALEIMIDE IX METHANESULPHONATE SALT;BisindolylMaleiMide IX Mesylate;BisindolylMaleiMide IX . Methansulfonate [Ro 31-8220];Carbamimidothioic acid, 3-[3-[2,5-dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl]-1H-indol-1-yl]propyl ester, methanesulfonate (1:1);Ro31-8220MsOH | | CAS: | 138489-18-6 | | MF: | C25H23N5O2S | | MW: | 457.55 | | EINECS: | | | Product Categories: | Smad;TGF-beta;Inhibitors;TGF-beta/Smad;inhibitor | | Mol File: | 138489-18-6.mol |  |
| | RO-31-8220 Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMSO:52.77(Max Conc. mg/mL);95.31(Max Conc. mM)
DMF:25.0(Max Conc. mg/mL);45.15(Max Conc. mM)
DMF:PBS (pH 7.2) (1:9):0.1(Max Conc. mg/mL);0.18(Max Conc. mM)
Ethanol:2.77(Max Conc. mg/mL);5.0(Max Conc. mM) | | form | Red solid | | color | Red |
| | RO-31-8220 Usage And Synthesis |
| Description | Ro 31-8220 mesylate is a potent PKC inhibitor, inhibits PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC with IC50 values of 5, 24, 14, 27, 24 and 23 nM, also inhibits MAPKAP -K1b, MSK1, S6K1 and GSK3β with IC50 of 3, 8, 15, 38 nM. | | Uses | Ro 31-8220 Mesylate is a protein kinase C (PKC) inhibitor. | | General Description | Ro 31-8220 is a bisindolylmaleimide derivative of staurosporine. Ro 31-8220 blocks MAP kinase phosphatase-1 (MKP-1) expression, induces c-Jun expression and stimulates Jun N-terminal Kinase (JNK1). It has immunosuppressive properties. | | Biochem/physiol Actions | Inhibitor of GRK-5 (G protein-coupled receptor kinase); PKC (protein kinase C); MAPKAP kinase 1β and p70 S6 kinase. | | storage | +4°C |
| | RO-31-8220 Preparation Products And Raw materials |
|