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Ginsenoside Rg3

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Company Name: Shaanxi Haibo Biotechnology Co., Ltd
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Products Intro: Product Name:Ginsenoside Rg3
CAS:14197-60-5
Purity:98% Package:20mg-1g brown glass bottle, 25kg/drum Remarks:White to beige powder
Company Name: Shanghai Zheyan Biotech Co., Ltd.
Tel: 18017610038
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Products Intro: Product Name:Ginsenoside Rg3
CAS:14197-60-5
Purity:HPLC>=98% Package:20mg
Company Name: career henan chemical co
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Email: sales@coreychem.com
Products Intro: Product Name:Ginsenoside Rg3
CAS: 14197-60-5
Purity:99% Package:1kg;7USD
Company Name: Chengdu Biopurify Phytochemicals Ltd.
Tel: +8618080483897
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Products Intro: Product Name:Ginsenoside Rg3
CAS:14197-60-5
Purity:0.98 Package:10mg;20mg;50mg;100mg;500mg Remarks:Can Be Customized in Bulk
Company Name: Nanjing Dolon Biotechnology Co.,Ltd.
Tel: 18905173768
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Products Intro: Product Name:Ginsenoside Rg3
CAS:14197-60-5

Ginsenoside Rg3 manufacturers

  • Ginsenoside Rg3
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  • $0.00 / 25kg
  • 2023-11-08
  • CAS:14197-60-5
  • Min. Order: 1kg
  • Purity: 98%
  • Supply Ability: 2000ton
  • Ginsenoside Rg3
  • Ginsenoside Rg3 pictures
  • $0.00 / 20mg
  • 2023-02-24
  • CAS:14197-60-5
  • Min. Order: 5mg
  • Purity: ≥96%(HPLC)
  • Supply Ability: 10 g

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Ginsenoside Rg3 Basic information
Product Name:Ginsenoside Rg3
Synonyms:beta-d-glucopyranoside,(3-beta,12-beta)-12,20-dihydroxydammar-24-en-3-yl2-o-b;dammar-24-ene-12-beta,20-diol,3-beta-((2-o-beta-d-glucopyranosyl-beta-d-gluc;eta-d-glucopyranosyl-;gensenoside RG3;(3β,12β)-12,20-Dihydroxydammar-24-en-3-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside;Rg3;GINSENOSIDE RG3;opyransoyl)oxy)-
CAS:14197-60-5
MF:C42H72O13
MW:785.03
EINECS:
Product Categories:chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Ginsenoside series;Saponins;The group of Ginsenosides
Mol File:14197-60-5.mol
Ginsenoside Rg3 Structure
Ginsenoside Rg3 Chemical Properties
Melting point 315-318°C
Boiling point 885.0±65.0 °C(Predicted)
density 1.30
storage temp. 2-8°C
solubility DMSO: ≥5mg/mL
pka12.85±0.70(Predicted)
form powder
color white to beige
optical activity[α]/D +10 to +20°, c = 1 in methanol
InChIKeyRWXIFXNRCLMQCD-JBVRGBGGSA-N
CAS DataBase Reference14197-60-5(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 22
WGK Germany 3
RTECS LY9537300
HS Code 29389090
Toxicitymouse,LD50,intraperitoneal,1250mg/kg (1250mg/kg),Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 343, 1975.
MSDS Information
Ginsenoside Rg3 Usage And Synthesis
DescriptionGinsenosides are pharmacologically active natural constituents of ginseng and other plants of the genus Panax. Structurally, they are steroid glycosides derived from the triterpene squalene. Ginsenoside Rg3 is a panaxadiol found in white and red P. ginseng. This ginsenoside has diverse in vitro and in vivo effects, including anti-cancer, neuroprotective, anti-hypertensive, and anti-inflammatory actions. Ginsenoside Rg3 induces apoptosis and inhibits angiogenesis in a variety of cancer models. Notably, this ginsenoside can be produced by heating other ginsenosides, leading to elevated levels in steamed or dried ginseng preparations.
UsesGinsenoside Rg3 shows a synergistic antitumor effect with cisplatin in cisplatin-resistant bladder tumor cell lines and is considered to be an anti-tumor agent.
UsesGinsenoside Rg3 has been used to investigate its modulatory effects on delayed rectifier potassium current (IKr) channels in long QT syndrome (LQTS)2-human induced pluripotent stem cells (hiPSC-CMs).
DefinitionChEBI: (20S)-ginsenoside Rg3 is a ginsenoside found in Panax ginseng and Panax japonicus var. major that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy group at position 3 has been converted to the corresponding beta-D-glucopyranosyl-beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position. It has a role as an apoptosis inducer, an antineoplastic agent, a plant metabolite and an angiogenesis modulating agent. It is a ginsenoside, a tetracyclic triterpenoid and a glycoside. It is functionally related to a (20S)-protopanaxadiol. It derives from a hydride of a dammarane.
Biochem/physiol ActionsGinsenoside Rg3 is a natural product isolated from Panax ginseng. Similar to other ginsenosides it exhibits cardio protective effects. Ginsenoside Rg3 enhances cardiac, hERG (IKr) and KCNQ (Iks), channel currents by interaction with the channel pore entryway. It also inhibits the palmitate-induced apoptosis of MIN6N8 mouse insulinoma beta-cells through modulating p44/42 MAPK activation. Ginsenoside Rg3 increases the level of the transcription factor Nrf2 and induces the mRNA levels of multidrug resistance-associated protein (Mrp) 1 and Mrp3. Rg3 modulate neuroinflammation by attenuating the activation of microglia in response to systemic LPS treatment. It activates AMPK in HepG2 cells and reduces the lipid accumulation thereby decreasing the risk of cardiovascular disease due to dyslipidemia.
Ginsenoside Rg3 Preparation Products And Raw materials
Tag:Ginsenoside Rg3(14197-60-5) Related Product Information
ginsenoside Rh(4) GINSENOSIDE RB2 Ginsenoside Rc Ginsenoside Rb1 Ginseng extract GinsenosideRo Ginsenoside Rg2 PANAX NOTOGINSENOSIDES Ginsenoside Re Ginsenoside Rh2 Escin Ginsenoside Rg1 GINSENOSIDE RE TRIBULOSIDE Ginsenoside Rd Ginsenoside Rf Ginsenoside CK 20(R)-Ginsenoside Rg3