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gamma-Butyrolactone

gamma-Butyrolactone Suppliers list
Company Name: Mainchem Co., Ltd.
Tel: +86-0592-6210733
Email: sales@mainchem.com
Products Intro: Product Name:gamma-Butyrolactone
CAS:96-48-0
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.
Tel: 86-0551-65418684 18949823763
Email: info@tnjchem.com
Products Intro: Product Name:gamma-Butyrolactone
CAS:96-48-0
Purity:99.9%min. Package:1KG;4USD
Company Name: hebei chisure biotechnology co.,ltd
Tel: 0311 66567340
Email: admin@SpeedGainpharma.com
Products Intro: Product Name:γ-Butyrolactone (GBL)
CAS:96-48-0
Purity:99% Package:10G;10USD
Company Name: Tianjin Zhongxin Chemtech Co., Ltd.
Tel: 022-89880739
Email: sales@tjzxchem.com
Products Intro: Product Name:gamma-Butyrolactone
CAS:96-48-0
Purity:99.5%Min Package:200kg drum Remarks:GBL
Company Name: Hebei Guanlang Biotechnology Co., Ltd.
Tel: +86-0311-66562153 whatsapp +8615203118427
Email: sales@crovellbio.com
Products Intro: Product Name:GBL
CAS:96-48-0
Purity:99% Package:Packaging(Various Packaging) Remarks:email: sales@crovellbio.com whatsapp/wechat: +8615203118427 skype: sales@crovellbio.com

Lastest Price from gamma-Butyrolactone manufacturers

  • gamma-Butyrolactone
  • US $60.00 / L
  • 2018-12-27
  • CAS:96-48-0
  • Min. Order: 60L
  • Purity: 99%
  • Supply Ability: 1000L/month
gamma-Butyrolactone Basic information
Chemical properties Uses Production Category Toxicity grading Acute toxicity Hazardous characteristics of the explosive Flammability hazard Storage and transportation properties Extinguishing agent
Product Name:gamma-Butyrolactone
Synonyms:FEMA 3291;GAMMA-BUTYROLACTONE;GAMA-BUTYROLACTONE;GAMMA-HYDROXYBUTYRIC ACID LACTONE;GBL;GBL-EL;G-BUTYROLACTONE;endo-cis-5-norbornene-endo-2,3-dicarboxylic anhydride
CAS:96-48-0
MF:C4H6O2
MW:86.09
EINECS:202-509-5
Product Categories:Pharmaceutical Intermediates;Heterocycles;-;Miscellaneous Reagents;Halogenated Heterocycles ,Thiophenes ,Thiazolines/Thiazolidines
Mol File:96-48-0.mol
gamma-Butyrolactone Structure
gamma-Butyrolactone Chemical Properties
Melting point −45 °C(lit.)
Boiling point 204-205 °C(lit.)
density 1.12 g/mL at 25 °C(lit.)
vapor density 3 (vs air)
vapor pressure 1.5 mm Hg ( 20 °C)
refractive index n20/D 1.436(lit.)
FEMA 3291 | 4-HYDROXYBUTANOIC ACID LACTONE
Fp 209 °F
storage temp. 2-8°C
form neat
explosive limit16%
Water Solubility MISCIBLE
Merck 13,1596
BRN 105248
Stability:Stable. Hygroscopic. Incompatible with strong oxidizing agents, strong acids, strong bases, strong reducing agents.
InChIKeyYEJRWHAVMIAJKC-UHFFFAOYSA-N
CAS DataBase Reference96-48-0(CAS DataBase Reference)
NIST Chemistry Reference«gamma»-Butyrolactone(96-48-0)
EPA Substance Registry System2(3H)-Furanone, dihydro-(96-48-0)
Safety Information
Hazard Codes Xn,F
Risk Statements 22-36-67-41-20/21/22-11
Safety Statements 26-36-39-36/37-16
WGK Germany 1
RTECS LU3500000
Autoignition Temperature851 °F
TSCA Yes
HS Code 29322980
Hazardous Substances Data96-48-0(Hazardous Substances Data)
ToxicityLD50 orally in rats: 17.2 ml/kg (Smyth)
MSDS Information
ProviderLanguage
BLO English
SigmaAldrich English
ACROS English
gamma-Butyrolactone Usage And Synthesis
Chemical propertiesColorless transparent liquid It is miscible with water and the general organic and slightly soluble in aliphatic hydrocarbons.
Uses
  • It is an important organic synthesis intermediate which can be used to synthesize indole butyric acid, butyric acid, succinic acid, α-pyrrolidone, N-methylpyrrolidone, vinyl pyrrolidone, acetyl-γ-butyrolactone, cyclopropylamine, ciprofloxacin, vitamin B1, chlorophyll and so on;
  • It is a non-toxic high boiling point solvent with high solubility and safe and convenient usage and management;
  • It is used as an extractant for butadiene, aromatic, advanced grease petroleum processing;
  • It is used as an acrylonitrile fiber spinning solvent in the chemical fiber industry. 
  • It is a thinner and curing agent commonly used in wool, nylon, acrylonitrile and other fiber dyeing auxiliaries and other chemical industries.
ProductionMaleic anhydride hydrogenation method is an advanced technology developed in 1970s. It can produce tetrahydrofuran and γ-butyrolactone in any proportion with a hydrogenation reaction, and the usual ratio is tetrachlorofuran: γ-butyrolactone = 3-4:1.
There are many production enterprises, but usually in small scale. The average level is 300t/a. The production capacity account for 30% of the total domestic production capacity.  2.1, 4-butanediol dehydrogenation reactor is a tube array reactor, filled with flake copper catalyst (with zinc oxide as the carrier). The reaction temperature is controlled at 230-240 ° C. The yield of the product is obtained by reduced pressure distillation of and the yield is above 77%.
CategoryFlammable substance
Toxicity gradingMiddle
Acute toxicityoral-rat LD50: 1540 mg/kg; oral-mouse LD50: 1720 mg/kg
Hazardous characteristics of the explosiveExplosible when react with butanol, 2,4-dichlorophenol and sodium hydroxide
Flammability hazardFlammable in case of heat, open flame; being able to react with oxidant; releasing toxic pungent smoke when in the process of pyrolysis.
Storage and transportation propertiesMake sure ventilating, low temperature and drying in the warehouse; separate from the oxidant; prevent fires.
Extinguishing agentDry powder, carbon dioxide, foam
Chemical Propertiescolourless oily liquid
Chemical PropertiesOily, colorless, clear liquid. Faint, pleasant odor.
Usesr-butyrolactone is one kind of important fine chemicalintermediate, simultaneously also is one kind of performance fine highboiling point solvent, ideal antioxidant, plasticizer,extracting agent, absorbent, dispersing agent, solid stain, Coagulation Reagent.
DefinitionChEBI: A butan-4-olide that is tetrahydrofuran substituted by an oxo group at position 2.
UsesIntermediate in the synthesis of polyvinylpyrrolidone, DL-methionine, piperidine, phenylbutyric acid, thiobutyric acids. Solvent for polyacrylonitrile, cellulose acetate, methyl methacrylate polymers, polystyrene. Constituent of paint removers, textile aids, drilling oils.
General DescriptionClear colorless oily liquid with a pleasant odor.
Air & Water ReactionsHygroscopic. Soluble in water.
Reactivity Profilegamma-Butyrolactone can react with oxidizing materials, inorganic acids and bases, alcohols and amines. Rapidly hydrolyzed by bases and slowly hydrolyzed by acids. gamma-Butyrolactone is volatile with steam. . The combination of the lactone, butanol, 2,4-dichlorophenol, and sodium hydroxide in the attempted synthesis of 2,4-dichlorophenoxybutyric acid caused a thermal runaway reaction that eventually exploded, [CISHC Chem. Safety Summ., 1977, 48, 3].
HazardToxic by ingestion. Questionable carcino- gen.
Fire Hazardgamma-Butyrolactone is combustible.
Safety ProfileModerately toxic by ingestion, intravenous, and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data by skin contact. Mutation data reported. Less acutely toxic than ppropiolactone. Combustible when exposed to heat or flame; can react with oxidizing materials. To fight fire, use foam, alcohol foam, CO2, dry chemical. Potentially explosive reaction with butanol + 2,4 dichlorophenol + sodium hydroxide. When heated to decomposition it emits acrid and irritating fumes.
Potential ExposureUsed as a chemical intermediate for making other chemicals, including pesticides, cosmetics, and pharmaceuticals; as a solvent for paint, nail polish removers, and industrial chemicals. Used in electronics, drilling and petroleum industries as a stabilizer and solvent. Used as a flavoring agent in various foods and beverages, including grains and breakfast foods, candy, and alcoholic and nonalcoholic drinks. Drug of abuse: the United States Food and Drug Administration has warned the public not to purchase or consume products, containing gamma-butyrolactone (GBL). FDA has also asked the companies that manufacture these products to voluntarily recall them. The agency has received reports of serious health problems—some that are potentially life-threatening—associated with the use of these products. Although labeled as dietary supplements and marketed under various brand names, these products are illegally marketed unapproved new drugs. False advertising claims include building muscles, improved physical performance, enhanced sex, reduced stress and induced sleep
First aidEyes: first check the victim for contact lenses and remove if present. Flush victim’s eyes with water or normal saline solution for 20 to 30 minutes. Simultaneously, call a hospital or poison control center. Do not put any ointments, oils, or medication in the victim’s eyes without specific instructions from a physician. Immediately transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. Skin: immediately flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, immediately call a physician and be prepared to transport the victim to a hospital for treatment. Inhalation: immediately leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be preparedto transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, SCBA should be used; if not available, use a level of protection greater than or equal to that advised under protective clothing. Ingestion: do not induce vomiting. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and immediately call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim’s airway is open and lay the victim on his/her side with the head lower than the body. Do not induce vomiting. Immediately transport the victim to a hospital.
ShippingListed by some sources as unregulated. UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1—Poisonous materials, Technical Name Required.
Purification MethodsDry the lactone over anhydrous CaSO4, then fractionally distil it. Handle it in a fume cupboard due to its TOXICITY. [Beilstein 17 V 7.]
Incompatibilities4-Butyrolactone is incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, alcohols, amines, strong and inorganic acids, strong bases. Rapidly hydrolyzed by bases and slowly hydrolyzed by acids. It is hygroscopic and volatile with steam. Combustible; vapor may form explosive mixture with air.
Waste DisposalUse a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. It is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator. All federal, state, and local environmental regulations must be observed.
Tag:gamma-Butyrolactone(96-48-0) Related Product Information
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