| Company Name: |
VDM Biochemicals
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| Tel: |
0330-2528181 |
| Email: |
sales@vdmbio.com |
| Products Intro: |
Product Name:MMP Inhibitor II
CAS:203915-59-7
Purity:>=95%
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:MMP Inhibitor II
CAS:203915-59-7
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
| Company Name: |
MedBioPharmaceutical Technology Inc
|
| Tel: |
021-69568360 18916172912 |
| Email: |
order@med-bio.cn |
| Products Intro: |
Product Name:MMP INHIBITOR II
CAS:203915-59-7
Purity:98% Package:10mg; 1mg; 5mg Remarks:Medbio
|
| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:MMP Inhibitor II
CAS:203915-59-7
Purity:95% Package:1mg;5mg;10mg
|
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| | MMP INHIBITOR II Basic information |
| Product Name: | MMP INHIBITOR II | | Synonyms: | N-HYDROXY-1,3-DI-(4-METHOXYBENZENESULPHONYL)-5,5-DIMETHYL-[1,3]-PIPERAZINE-2-CARBOXAMIDE;MMP INHIBITOR II;N-hydroxy-1,3-bis[(4-methoxyphenyl)sulfonyl]-5,5-dimethyl-1,3-diazinane-2-carboxamide;2-Pyrimidinecarboxamide, hexahydro-N-hydroxy-1,3-bis[(4-methoxyphenyl)sulfonyl]-5,5-dimethyl- | | CAS: | 203915-59-7 | | MF: | C21H27N3O8S2 | | MW: | 513.58 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | MMP INHIBITOR II Chemical Properties |
| density | 1.385±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble in DMSO | | form | Solid | | pka | 9.53±0.23(Predicted) |
| | MMP INHIBITOR II Usage And Synthesis |
| Uses | A potent, reversible, broad range inhibitor of matrix metalloproteinases | | Biological Activity | mmp inhibitor ii is a potent, reversible and broad-range inhibitor of matrix metalloproteinases (mmps) with ic50 values of 24 nm, 18.4 nm, 30 nm and 2.7 nm for mmp-1, mmp-3, mmp-7 and mmp-9, respectively [1].mmps belong to a family of at least fifteen secreted and membrane-bound zinc-endopeptidases. mmps have been engaged in several pathological processes, including tumor growth and metastasis, arthritis, multiple sclerosis, and periodontal disease. these enzymes play a vital role in tissue repair and remodeling via degrading all the extracellular matrix components, including fibrallar and non-fibrallar collagens, laminin, fibronectin, and basement membrane glycoproteins, which enables cell migration. in addition, mmps exert function in metastasis by promoting tumor invasion and angiogenesis. it was shown that the expression of various members of the mmp family by tumors is closely associated with their proliferative and invasive behavior and metastatic potential. furthermore, mmps are broadly sub-divided into three classes: stromelysins, gelatinases, and collagenases, which are secreted in a proenzyme form and require activation to digest an extracellular matrix [1]. | | references | [1]. slawomir m. wojtowicz-praga, robert b. dickson and michael j. hawkins. matrix metalloproteinase inhibitors. investigational new drugs. 1997; 15: 61–75. |
| | MMP INHIBITOR II Preparation Products And Raw materials |
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