| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:Ro 106-9920
CAS:62645-28-7
Package:250Mg,25Mg
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| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:Ro 106-9920;6-(Phenylsulfinyl)tetrazolo[1,5-b]pyridazine
CAS:62645-28-7
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
Chemsky (shanghai) International Co.,Ltd
|
| Tel: |
021-50135380 |
| Email: |
shchemsky@sina.com |
| Products Intro: |
Product Name:Ro 106-9920;6-(Phenylsulfinyl)tetrazolo[1,5-b]pyridazine
CAS:62645-28-7
Purity:98+% Package:1Mg;5Mg;10Mg;50Mg;100Mg;500Mg
|
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| | RO 106-9920 Basic information |
| | RO 106-9920 Chemical Properties |
| storage temp. | Store at +4°C | | solubility | Soluble to 5 mM in ethanol and to 100 mM in DMSO | | form | White solid |
| | RO 106-9920 Usage And Synthesis |
| Uses | Ro 106-9920 is an inhibitor of NF-κB activation, possibly via selective inhibition of LPS- and TNF-α-induced IκBα ubiquitination (IC50 = 3 μM). Ro 106-9920 blocks subsequent production of TNF-α, IL-1β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo. Also weakly inhibits EGFR, 5-lipoxygenase and iNOS. | | Definition | ChEBI: 6-(benzenesulfinyl)tetrazolo[1,5-b]pyridazine is a sulfoxide. | | Biological Activity | Inhibitor of NF- κ B activation, possibly via selective inhibition of LPS- and TNF- α -induced I κ B α ubiquitination (IC 50 = 3 μ M). Blocks subsequent production of TNF- α , IL-1 β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo . Also weakly inhibits EGFR, 5-lipoxygenase and iNOS. |
| | RO 106-9920 Preparation Products And Raw materials |
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