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| | 2-FLUORO-5-HYDROXYPYRIDINE Basic information |
| | 2-FLUORO-5-HYDROXYPYRIDINE Chemical Properties |
| Melting point | 148-150°C | | Boiling point | 319.8±22.0 °C(Predicted) | | density | 1.325±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | soluble in Methanol | | form | powder to crystal | | pka | 9.03±0.10(Predicted) | | color | White to Almost white | | CAS DataBase Reference | 55758-32-2(CAS DataBase Reference) |
| | 2-FLUORO-5-HYDROXYPYRIDINE Usage And Synthesis |
| Chemical Properties | White fine crystalline powder | | Synthesis | 5-Acetoxy-2-fluoropyridine (2.26 g, 14.6 mmol, from Step 8d) was used as raw material and dissolved in 20% aqueous NaOH (15 mL). The reaction mixture was stirred at room temperature for 1 hour. Subsequently, the reaction solution was neutralized with concentrated HCl. The aqueous phase was extracted with ethyl acetate. The organic phases were combined, dried with anhydrous MgSO4 and concentrated under reduced pressure to remove the solvent. Purification by silica gel column chromatography (eluent: CHCl3/MeOH, 98:2) afforded 1.31 g of the target product 2-fluoro-5-hydroxypyridine in 79% yield. Mass spectra (MS) m/z: 114 (M + H)+, 131 (M + NH4)+; 1H NMR (CDCl3, 300 MHz) δ 6.84 (dd, J = 1.85,5.14 Hz, 1H), 7.43 (m, 1H), 7.81 (t, J = 2.84 Hz, 1H). | | References | [1] Patent: US6001849, 1999, A
[2] Patent: US6133253, 2000, A |
| | 2-FLUORO-5-HYDROXYPYRIDINE Preparation Products And Raw materials |
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