| Company Name: |
ShangHai Caerulum Pharma Discovery Co., Ltd.
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| Tel: |
18149758185 |
| Email: |
sales-cpd@caerulumpharma.com |
| Products Intro: |
Product Name:4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID
CAS:331830-20-7
Purity:98% Package:10mg;100mg;1g;10g;100g;1kg
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| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:1,4-DPCA
CAS:331830-20-7
Purity:98% Package:1G;10G;100G Remarks:The pro-angiogenic factor HIF-1α is targeted for destruction in non-hypoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-α prolyl hydroxylase
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| Product Name: | 4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID | | Synonyms: | 4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID;1,4-DPCA;TVBAVFFTADCWKG-UHFFFAOYSA-N;4-DPCA;HIF-PH,HIF/HIF Prolyl-Hydroxylase,HIF-1α,HIFs,FIH,P4HA1,P4HA2,1,4DPCA,healing,Inhibitor,Hypoxia-inducible factors,1,4 DPCA,wound,inhibit,1,4-DPCA,P4HA3;1,10-Phenanthroline-3-carboxylic acid, 4,4a-dihydro-4-oxo- | | CAS: | 331830-20-7 | | MF: | C13H8N2O3 | | MW: | 240.21 | | EINECS: | | | Product Categories: | | | Mol File: | 331830-20-7.mol | ![4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID Structure](CAS/GIF/331830-20-7.gif) |
| | 4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID Chemical Properties |
| Boiling point | 419.5±45.0 °C(Predicted) | | density | 1.52±0.1 g/cm3(Predicted) | | storage temp. | RT | | solubility | Soluble in DMSO (up to 15 mg/ml with warming). | | form | Tan solid. | | pka | 2.55±0.20(Predicted) | | color | Off-white | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months. |
| | 4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID Usage And Synthesis |
| biological activity | 1,4-DPCA, a potent and selective inhibitor of prolyl-4-hydroxylase, is also an inhibitor of collagen hydroxylation in chemicalbook cells of human foreskin fibroblasts with IC50 of 2.4µM. 1,4-DPCA inhibits the alpha isoform of prolyl-4-hydroxylase and stabilizes HIF-1alpha protein. | | Description | 1,4-DPCA (331830-20-7) is a potent inhibitor of prolyl 4-hydroxylase (IC50=2-4 μM).1 Inhibits collagen deposition via inhibition of collagen proline hydroxylation.2,3 Subcutaneous injection of a 1,4-DPCA containing hydrogel into Swiss Webster mice that do not show a regenerative phenotype increased expression of HIF1α over 5 days. Multiple injections led to regenerative wound healing after ear hole punch injury.4 | | Uses | 1,4-DPCA nis a potent competitive inhibitor of avian prolyl 4-hydroxylase in embryonic chick tendon cells and human foreskin fibroblasts in vitro. It is a promotor of wound healing and tissue regeneration in mice. | | References | 1) Franklin?et al. (2001),?Inhibition of prolyl 4-hydroxylase in vitro and in vivo by members of a novel series of phenanthrolinones; Biochem. J.,?353?333
2) Xiong?et al. (2014),?Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition; BMC Cancer,?14?1
3) Love and Jones?et al. (2013),?Transient inhibition of connective tissue infiltration and collagen deposition into porous poly(lactic-co-glycolic acid) discs; J. Biomed. Mater. Res.,?101?3599
4) Zhang?et al. (2015),?Drug induced regeneration in adult mice; Sci. Transl. Med.,?7?290ra92 |
| | 4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID Preparation Products And Raw materials |
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