- a-amyrin
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- $2.00 / 1KG
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2022-02-25
- CAS:638-95-9
- Min. Order: 100g/Bag
- Purity: 99%
- Supply Ability: 30tons
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| | alpha-Amyrin Basic information |
| Product Name: | alpha-Amyrin | | Synonyms: | Urs-12-en-3β-ol, Viminalol;(3S,4aR,6aR,6bS,8aR,11R,12S,12aR,14aR,14bR)-4,4,6a,6b,8a,11,12,14b-Octamethyl-2,3,4a,5,6,7,8,9,10,11,12,12a,14,14a-tetradecahydro-1H-picen-3-ol;3b-Hydroxyurs-12-ene;Urs-12-en-3-ol, (3b)-;α-Amyrin,Urs-12-en-3β-ol, Viminalol;A-AMYRIN WITH HPLC;alpha-AMYRIN hplc;A-AMYRIN | | CAS: | 638-95-9 | | MF: | C30H50O | | MW: | 426.73 | | EINECS: | 211-352-1 | | Product Categories: | Tri-Terpenoids;Building block | | Mol File: | 638-95-9.mol |  |
| | alpha-Amyrin Chemical Properties |
| Melting point | 178-183°C | | alpha | D17 +91.6° (c = 1.3 in benzene) | | Boiling point | bp0.7 243° | | density | 0.9600 (rough estimate) | | refractive index | 1.4910 (estimate) | | solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) | | pka | 15.18±0.70(Predicted) | | form | Solid | | color | White to off-white | | optical activity | +93.3 (c 5.55, C6H6) | | BRN | 1916550 | | LogP | 10.636 (est) | | CAS DataBase Reference | 638-95-9(CAS DataBase Reference) | | NIST Chemistry Reference | «ALPHA»-amyrin(638-95-9) | | EPA Substance Registry System | Urs-12-en-3-ol, (3.beta.)- (638-95-9) |
| Hazard Codes | Xi | | WGK Germany | 3 |
| | alpha-Amyrin Usage And Synthesis |
| Uses | a-Amyrin is a natural chemical compound of the triterpene class. It is a pentacyclic triterpenol widely distributed in nature and has been isolated from a variety of plant sources such as epicuticular wax. | | Definition | ChEBI: A pentacyclic triterpenoid that is ursane which contains a double bond between positions 12 and 13 and in which the hydrogen at the 3beta position is substituted by a hydroxy group. | | Biological Activity | Triterpene th at has broad-spectrum analgesic properties for which the underlying mechanism is poorly understood but which may involve the inhibition of protein kinase A (PKA). | | in vivo | α-Amyrin (50, 100, 200 mg/kg orally, once daily for 42 days) can reduce the survival rate of rats with metabolic syndrome induced by high fructose diet[2].
α-Amyrin (2 or 4 mg/kg, orally) improves cognitive dysfunction caused by low cholinergic neurotransmission in mice by activating ERK and GSK-3β signaling pathways[3].
| Animal Model: | High-fructose diet (HFD)-induced metabolic syndrome in rats[2] | | Dosage: | 50, 100, 200 mg/kg | | Administration: | p.o. | | Result: | Decreased systolic blood pressure, plasma glucose, total cholesterol, and plasma triglycerides.
Attenuated hepatic oxidative stress as well as micro- and macrovesicular fatty changes in hepatocytes caused by HFD.
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| Animal Model: | Scopolamine-Induced Memory Impairment Mice[3] | | Dosage: | 2 or 4 mg/kg | | Administration: | p.o. | | Result: | Increased the expression levels of phosphorylated extracellular signal-regulated kinase 1/2 (pERK) and phosphorylated glycogen synthase kinase-3β (pGSK-3β). |
| | Purification Methods | Purify it by acetylation to the acetate followed by hydrolysis and recrystallisation from aqueous MeOH or from EtOH. The acetate when crystallised from pet ether, n-heptane or CHC |
| | alpha-Amyrin Preparation Products And Raw materials |
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