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| | 2-GUANIDINOBENZIMIDAZOLE Basic information |
| | 2-GUANIDINOBENZIMIDAZOLE Chemical Properties |
| Melting point | 242-244 °C (dec.) (lit.) | | Boiling point | 296.48°C (rough estimate) | | density | 1.2954 (rough estimate) | | refractive index | 1.6900 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | solubility | Soluble in DMSO (up to 50 mg/ml) or in Water (up to 4 mg/ml with warming) | | form | solid | | pka | 13.67±0.30(Predicted) | | color | Beige | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. | | CAS DataBase Reference | 5418-95-1(CAS DataBase Reference) | | EPA Substance Registry System | Guanidine, 1H-benzimidazol-2-yl- (5418-95-1) |
| WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 2933998090 |
| | 2-GUANIDINOBENZIMIDAZOLE Usage And Synthesis |
| Description | 2GBI (5418-95-1) is a selective and state-dependent blocker of voltage-gated proton channels (Hv1).1?2GBI blocks the channel by binding to the voltage-sensing domain from its intracellular side.2,3? Inhibition of Hv1 is a potentially new target of intervention in various pathophysiological processes including inflammatory, cancer, bone resorption and neurodegenerative disease.4 | | Chemical Properties | BROWN-PURPLE FINE CRYSTALLINE POWDER | | Uses | N-1H-Benzimidazol-2-ylguanidine is used as a reagent in the synthesis of novel fused pyrimidines and imidazoles as potential analgesics. | | Definition | ChEBI: 2-Benzimidazolylguanidine is an aminoimidazole. | | References | 1) Hong?et al. (2015),?Interrogation of the intersubunit interface if the open Hv1 proton channel with a probe of allosteric coupling; Sci. Rep.,?5?14077
2) Hong?et al.?(2014),?Molecular determinants of Hv1 proton channel inhibition by guanidine derivatives; Proc. Natl. Acad. Sci. USA,?111?9971
3) Gianti?et al. (2016),?On the role of water density fluctuations in the inhibition of a proton channel; Proc. Natl. Acad. Sci. USA,?113?E8359
4) Pupo and Gonzalez (2014),?In pursuit of an inhibitory drug for the proton channel; Proc. Natl. Acad. Sci. USA,?111?9673 |
| | 2-GUANIDINOBENZIMIDAZOLE Preparation Products And Raw materials |
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