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| | Methylmagnesium chloride Basic information |
| | Methylmagnesium chloride Chemical Properties |
| Boiling point | 66 °C | | density | 1.013 g/mL at 25 °C | | Fp | −1 °F | | storage temp. | Store below +30°C. | | solubility | Miscible with diethyl ether and tetrahydrofuran. | | form | Liquid | | color | Pale brown to dark green | | Water Solubility | reacts | | Sensitive | Air & Moisture Sensitive | | BRN | 3587199 | | Exposure limits | ACGIH: TWA 50 ppm; STEL 100 ppm (Skin)
OSHA: TWA 200 ppm(590 mg/m3)
NIOSH: IDLH 2000 ppm; TWA 200 ppm(590 mg/m3); STEL 250 ppm(735 mg/m3) | | CAS DataBase Reference | 676-58-4(CAS DataBase Reference) | | EPA Substance Registry System | Magnesium, chloromethyl- (676-58-4) |
| | Methylmagnesium chloride Usage And Synthesis |
| Chemical Properties | dark brown solution | | Uses | Methylmagnesium chloride is used as a Grignard reagent and an alkylating agent in organic synthesis. | | Definition | ChEBI: Methylmagnesium chloride is an alkylmagnesium halide and a one-carbon compound. available as a solutionin tetrahydrofuran. | | Application | Methylmagnesium chloride solution (3 M in THF) undergoes 1,3-addition with dialdose derived nitrones to form N-benzylhydroxylamines. The reductive cleavage of the N-O bond of these N-benzylhydroxylamines results in N-benzylaminosugars, which are key moieties of bioactive compounds. It can also react with Garner type aldehydes to form the corresponding secondary alcohols. | | Preparation | reaction of methyl chloride and magnesium in anhydrous diethyl ether, usually in the presence of an initiator. | | Reactions | Methylmagnesium chloride can react with acidic hydrogen on oxygen, sulfur and alkyne carbon of compounds containing active hydrogen (such as water, alcohol, mercaptan, amine, amide, acid, sulfonic acid, etc.); Propyl bromide, etc.) undergoes a coupling reaction; it can react with oxygen and carbon dioxide, aldehydes, ketones, etc. | | Hazard | Flammable, dangerous fire and explosionrisk. |
| | Methylmagnesium chloride Preparation Products And Raw materials |
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