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Tetracaine

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Products Intro: Product Name:Tetracaine Base cas 94-24-6 (whatsapp:+8618830163278)
CAS:94-24-6
Purity:99.8% Package:1kg;4USD
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CAS:94-24-6
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CAS:94-24-6
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Products Intro: Product Name:Tetracaine Base
CAS:94-24-6
Company Name: Shenzhen Sendi Biotechnology Co.Ltd.
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Products Intro: Product Name:Tetracaine
CAS:94-24-6
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Lastest Price from Tetracaine manufacturers

  • Tetracaine
  • US $100.00 / kg
  • 2019-05-22
  • CAS:94-24-6
  • Min. Order: 100g
  • Purity: 99.9%
  • Supply Ability: 10TONS
  • Tetracaine
  • US $10.00 / KG
  • 2019-04-30
  • CAS:94-24-6
  • Min. Order: 10UG
  • Purity: 99%
  • Supply Ability: 500kg/month
Tetracaine Basic information
Description Mechanism of Action Precautions Application Dosage Side Effects
Product Name:Tetracaine
Synonyms:2-(Dimethylamino)ethyl 4-(butylamino)benzoate;2-(Dimethylamino)ethyl p-(butylamino)benzoate;2-Dimethylaminoethylester kyseliny p-butylaminobenzoove;2-dimethylaminoethylesterkyselinyp-butylaminobenzoove;2-dimethylaminoethylp-butylaminobenzoate;4-(butylamino)-benzoicaci2-(dimethylamino)ethylester;amethocaine;Anetain
CAS:94-24-6
MF:C15H24N2O2
MW:264.36
EINECS:202-316-6
Product Categories:Pharmaceutical Intermediates-;-;API;medical intermediate
Mol File:94-24-6.mol
Tetracaine Structure
Tetracaine Chemical Properties
Melting point 41.0 to 45.0 °C
Boiling point 407.59°C (rough estimate)
density 1.0200 (rough estimate)
refractive index 1.5800 (estimate)
storage temp. 2-8°C
pkapKa 8.33±0.03(H2O t = 20.0 I = 0.10 (KCl)) (Uncertain)
InChIKeyGKCBAIGFKIBETG-UHFFFAOYSA-N
CAS DataBase Reference94-24-6(CAS DataBase Reference)
NIST Chemistry ReferenceTetracaine(94-24-6)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 22-40-42/43-43
Safety Statements 22-36/37
RIDADR UN 2811
WGK Germany 3
RTECS DG4725000
HazardClass 6.1
PackingGroup III
HS Code 29224999
MSDS Information
Tetracaine Usage And Synthesis
DescriptionTetracaine is a local anesthetic or numbing medicine that is used to numb the throat, eyes, or nose. Normally, the drug is administered before starting a surgery to decrease pain from the procedure. Tetracaine is applied to the eyes 30 minutes before the start of an intravenous and its effects can last up to 15 minutes.
Mechanism of ActionTetracaine acts by blocking the nerve systems. It does this by blocking the sodium ion channels needed for the conduction and initiation of neural impulses, thereby affecting the local anesthesia. Tetracaine acts by altering the function of calcium release channels that controls the release of calcium frim intracellular cells.
PrecautionsNo studies have revealed whether the medicine can affect an unborn child; however, it is important to inform the doctor if pregnant while using it.

Informing the doctor is paramount if breastfeeding a baby, as no known research has illustrated whether tetracaine can pass into breast milk or harm a nursing baby.

To make tetracaine safe, it is important to inform the doctor if one has a history of spinal or brain injury, heart diseases, eye problems, a blood vessel disorder, open sores, skin injury in the area where the medicine will be applied.

Tetracaine should never be orally taken since it is typically designed for use on the skin only. If the medicine gets in the mouth, nose, vagina, or rectum, rinse with water.
ApplicationTetracaine topical (for the skin) is used to numb various body parts before a surgical procedure or a medical test. Conversely, tetracaine ophthalmic drops are used as local anesthetic for the eyes.
DosageAlways follow all direction on the prescription label. Do not use the medicine in smaller or larger amounts or for longer than recommended.
Side EffectsSeek emergency medical advice in case of any of the following allergic reactions: difficult breathing, hives, swelling of the throat, tongue, lips, or face. Stop using the drug and call the physician if one has severe burning, swelling, stinging, or other irritation of the treated skin. Other alarming symptoms include eye watering, irritation, and increased sensitivity to light.

Common side effects include burning, stinging, or itching at the point of application of the medicine; numbness in places where tetracaine has been accidentally applied or skin redness or tenderness.

Nonclinical Toxicology
Studies conducted to reveal the genotoxicity of tetracaine have not indicated its mutagenesis, carcinogenicity, or impairment of fertility.
Chemical PropertiesWhite or light-yellow, waxy solid. Very slightly soluble in water; soluble in alcohol, ether, benzene, chloroform.
Usesanalgesic
DefinitionChEBI: A benzoate ester in which 4-N-butylbenzoic acid and 2-(dimethylamino)ethanol have combined to form the ester bond; a local ester anaesthetic (ester caine) used for surface and spinal anaesthesia.
Biological FunctionsTetracaine hydrochloride (Pontocaine) is an ester of PABA that is an effective topical local anesthetic agent and also is quite commonly used for spinal (subarachnoid) anesthesia. Epinephrine is frequently added to prolong the anesthesia.Tetracaine is considerably more potent and more toxic than procaine and cocaine. It has approximately a 5-minute onset and 2 to 3 hours of action.
General DescriptionTetracaine was developed to address the low potency andshort duration of action of procaine and chloroprocaine. The addition of the butyl side chain on the para nitrogen increasesthe lipid solubility of the drug and enhances the topical potencyof tetracaine. The plasma half-life is 120 to 150 seconds.Topically applied tetracaine to unbroken skin requires 30 to 45minutes to confer topical anesthesia. Tetracaine 4% gel is superiorthan eutectic mixture with lidocaine (EMLA) (an emulsionof lidocaine and prilocaine) in preventing pain associatedwith needle procedures in children. Tetracaine metabolism issimilar to procaine ester metabolism yielding parabutylaminobenzoicacid and dimethylaminoethanol and conjugatesexcreted in the urine. The pKa of the dimethylated nitrogen is8.4 and tetracaine is formulated as a hydrochloride salt with apH of 3.5 to 6.0. The increased absorption from topical siteshas resulted in reported toxicity. Overdoses of tetracaine mayproduce central nervous system (CNS) toxicity and seizure activitywith fatalities from circulatory depression reported.No selective cardiac toxicity is seen with tetracaine althoughhypotension has been reported. Tetracaine is employed for infiltrationanesthesia, spinal anesthesia, or topical use.
Tetracaine Preparation Products And Raw materials
Tag:Tetracaine(94-24-6) Related Product Information
TETRACAINE HYDROCHLORIDEIMP. B (PHARMEUROPA): 4-(BUTYLAMINO)BENZOIC ACID TETRACAINE HYDROCHLORIDE IMP. A (PHARMEUROPA): 4-AMINOBENZOIC ACID Butyldiglycol THYMOPOIETIN II (32-35) 4-AMINOBENZOIC ACID ISOBUTYL ESTER BENZOIC ACID, 2-(BENZYLOXY)-4-BUTYLAMINO-, 2-(DIMETHYLAMINO)ETHYL ESTE R T 61 TETRACAINE, [CARBONYL-14C]- Hydroxytetracaine Tetracaine-d6 Hydrochloride LABOTEST-BB LT00439808 Tetracaine TETRACAINE HYDROCHLORIDE LOCAL ANESTHETI C,Tetracaine HCl,USP,TETRACAINE HYDROCHLORIDE,TETRACAINE HCL BENZOICACID 4-Aminobenzoic acid Anthranilic acid Ethyl acetate TRIS(TRIMETHYLSILYL) PHOSPHATE