4-Pyrimidinamine, 6-[4-[3-(dimethylamino)propoxy]phenyl]-2-(methylsulfonyl)-N-[3-(1H-pyrazol-1-yl)propyl]-

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4-Pyrimidinamine, 6-[4-[3-(dimethylamino)propoxy]phenyl]-2-(methylsulfonyl)-N-[3-(1H-pyrazol-1-yl)propyl]- manufacturers

  • TP-238
  • TP-238 pictures
  • $1520.00
  • 2026-05-11
  • CAS:2415263-04-4
  • Purity:
  • Supply Ability: 10g
4-Pyrimidinamine, 6-[4-[3-(dimethylamino)propoxy]phenyl]-2-(methylsulfonyl)-N-[3-(1H-pyrazol-1-yl)propyl]- Basic information
Product Name:4-Pyrimidinamine, 6-[4-[3-(dimethylamino)propoxy]phenyl]-2-(methylsulfonyl)-N-[3-(1H-pyrazol-1-yl)propyl]-
Synonyms:4-Pyrimidinamine, 6-[4-[3-(dimethylamino)propoxy]phenyl]-2-(methylsulfonyl)-N-[3-(1H-pyrazol-1-yl)propyl]-;N-[3-(1-Pyrazolyl)propyl]-6-[4-[3-(dimethylamino)propoxy]phenyl]-2-(methylsulfonyl)pyrimidin-4-amine
CAS:2415263-04-4
MF:C22H30N6O3S
MW:458.58
EINECS:
Product Categories:
Mol File:2415263-04-4.mol
4-Pyrimidinamine, 6-[4-[3-(dimethylamino)propoxy]phenyl]-2-(methylsulfonyl)-N-[3-(1H-pyrazol-1-yl)propyl]- Structure
4-Pyrimidinamine, 6-[4-[3-(dimethylamino)propoxy]phenyl]-2-(methylsulfonyl)-N-[3-(1H-pyrazol-1-yl)propyl]- Chemical Properties
Boiling point 702.0±70.0 °C(Predicted)
density 1.25±0.1 g/cm3(Predicted)
pka9.25±0.28(Predicted)
Safety Information
MSDS Information
4-Pyrimidinamine, 6-[4-[3-(dimethylamino)propoxy]phenyl]-2-(methylsulfonyl)-N-[3-(1H-pyrazol-1-yl)propyl]- Usage And Synthesis
UsesTP-238 is a potent and selective dual CECR2/BPTF probe with IC50 values of 30 nM and 350 nM, respectively. TP-238 also inhibits BRD9 with a pIC50 of 5.9 and is less active against other 338 kinases[1][2].
IC 50CECR2: 30 nM (IC50); CECR2: 10 nM (Kd); CECR2: 7.5 (pIC50); BPTF: 350 nM (IC50); BPTF: 120 nM (Kd); BPTF: 6.5 (pIC50); BRD9: 5.9 (pIC50)
References[1] Michael A Clegg, et al. Advancements in the Development of non-BET Bromodomain Chemical Probes. ChemMedChem. 2019 Feb 19;14(4):362-385. DOI:10.1002/cmdc.201800738
[2] Peter D Ycas, et al. New Inhibitors for the BPTF Bromodomain Enabled by Structural Biology and Biophysical Assay Development. Org Biomol Chem. 2020 Jun 26. DOI:10.1039/d0ob00506a
4-Pyrimidinamine, 6-[4-[3-(dimethylamino)propoxy]phenyl]-2-(methylsulfonyl)-N-[3-(1H-pyrazol-1-yl)propyl]- Preparation Products And Raw materials
Tag:4-Pyrimidinamine, 6-[4-[3-(dimethylamino)propoxy]phenyl]-2-(methylsulfonyl)-N-[3-(1H-pyrazol-1-yl)propyl]-(2415263-04-4) Related Product Information
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