| Company Name: |
Daicel Chiral Technologies (China)CO.,LTD
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| Tel: |
021-50460086-9 15921403865 |
| Email: |
han_yajun@dctc.daicel.com |
| Products Intro: |
Product Name:VH032-C1-COOH
CAS:2172819-72-4
Purity:95% Package:250MG;1G Remarks:211424
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| | L-Prolinamide, N-(3-carboxy-1-oxopropyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Basic information |
| Product Name: | L-Prolinamide, N-(3-carboxy-1-oxopropyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- | | Synonyms: | L-Prolinamide, N-(3-carboxy-1-oxopropyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;VH 032 amide-alkylC2-acid;4-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-4-oxobutanoic acid;(S,R,S)-AHPC-amido-C2-acid;(S,R,S)-AHPC-C2-COOH;VH032-C1-COOH;(S,R,S)-CO-C2-acid;3-{[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}propanoic acid | | CAS: | 2172819-72-4 | | MF: | C26H34N4O6S | | MW: | 530.64 | | EINECS: | | | Product Categories: | | | Mol File: | 2172819-72-4.mol | ![L-Prolinamide, N-(3-carboxy-1-oxopropyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Structure](CAS/20210305/GIF/2172819-72-4.gif) |
| | L-Prolinamide, N-(3-carboxy-1-oxopropyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Chemical Properties |
| Boiling point | 868.3±65.0 °C(Predicted) | | density | 1.306±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | pka | 4.70±0.10(Predicted) | | form | Solid | | color | Off-white to light yellow |
| | L-Prolinamide, N-(3-carboxy-1-oxopropyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Usage And Synthesis |
| Description | (S,R,S)-AHPC-amido-C2-acid is a VHL ligand with a 2 carbon alkyl linker and terminal acid for PROTAC compounds. | | Uses | (S,R,S)-CO-C2-acid (VH 032 amide-alkylC2-acid) is a functionalized von-Hippel-Lindau (VHL) protein ligand that can be used in PROTAC research and development. (S,R,S)-CO-C2-acid contains an E3 ligand alkyl ligand for conjugation of target protein ligands[1]. | | storage | Store at -20°C | | References | [1] Chan KH, et al. Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds. J Med Chem. 2018 Jan 25;61(2):504-513. DOI:10.1021/acs.jmedchem.6b01912 |
| | L-Prolinamide, N-(3-carboxy-1-oxopropyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Preparation Products And Raw materials |
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