| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Email: |
eric_feng1954@126.com |
| Products Intro: |
Product Name:CHLORMERODRIN
CAS:62-37-3
Purity:95% -98%HPLC Package:1GR;10GR;50GR;100GR;250GR;500GR;1KG;5KG;10KG;100KG
|
|
| | chlormerodrin Basic information |
| Product Name: | chlormerodrin | | Synonyms: | MERCURY,CHLORO(2-METHOXY-3-UREIDOPROPYL)-;Diurone【diuretic】;Katonil;Mercoral;Merilid;Oricur;Percapyl;[3-(Chloromercuri)-2-methoxypropyl]urea | | CAS: | 62-37-3 | | MF: | C5H11ClHgN2O2 | | MW: | 367.197 | | EINECS: | 200-530-4 | | Product Categories: | | | Mol File: | 62-37-3.mol |  |
| | chlormerodrin Chemical Properties |
| Melting point | 152-153° | | Boiling point | 142°C | | form | solid |
| Toxicity | LD50 orally in rats: ~82 mg/kg (Goldenthal) |
| | chlormerodrin Usage And Synthesis |
| Originator | Neohydrin,Lakeside,US,1952 | | Uses | Chlormerodrin is a sulfhydryl blocking agent; using NK cells, particularly CAR-modified NK cells, for producing induced cellular vesicles (ICVs) loaded with chemotherapeutic agent(s) for cancer therapy. | | Definition | ChEBI: Chlormerodrin is urea in which one of the hydrogens is substituted by a 3-chloromercury-2-methoxyprop-1-yl group. It was formerly used as a diuretic, but more potent and less toxic drugs are now available. Its radiolabelled ((197)Hg, (203)Hg) forms were used in diagnostic aids in renal imaging and brain scans. It has a role as a diuretic and a diagnostic agent. It is an organomercury compound and a member of ureas. | | Manufacturing Process | To a refluxing solution of 100 g of allyl urea and 600 ml of absolute methanol
there was added with stirring a suspension of 319 g of mercuric acetate and
600 ml of absolute methanol and 60 ml of glacial acetate acid; complete
solution resulted. After 6 hours of refluxing, the solution was cooled and
clarified by filtration. To this solution there were added 50 g of sodium
chloride and 240 ml of water. After a short time a heavy white precipitate
settled out. This precipitate, which was 3-chloromercuri-2-methoxypropylurea, was filtered, washed and dried. | | Brand name | Mercloran (Parke-Davis); Neohydrin
(Marion Merrell Dow). | | Therapeutic Function | Diuretic |
| | chlormerodrin Preparation Products And Raw materials |
|